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ProteomicsRapid Tear Proteomics via In-Capillary Digestion for Biomarker Discovery
Tear fluid is emerging as a valuable resource for biomarker discovery, but its low sample volume and dynamic composition pose significant challenges for analytical testing. Most tear proteomics studies have focused on samples collected with Schirmer strips, while capillary tube collection has receiv...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056978 | Pride
1. tear proteomics  2. tear biomarker  3. biomarker discovery  4. point-of-care testing  5. poct  6. lc-ms/ms 
ProteomicsPrecision in Tear Fluid Biomarker Discovery: Quantitative Proteomic Profiling of Small-Volume, Individual Samples Using Capillary Tube Collection
Tear fluid, a complex biofluid that contains thousands of proteins and can be collected non-invasively, has emerged as a promising source of biomarkers for ocular and systemic health. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is currently the primary method for discovering novel biom...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060101 | Pride
1. tear proteomics  2. tear biomarker  3. biomarker discovery  4. capillary collection  5. lc-ms/ms 
ProteomicsInvestigation of inter- and intra-day variability of tear fluid regarding flow rate, protein concentration as well as protein composition
Purpose: Determination of inter- and intra-day variations in tear flow rate, tear fluid protein concentration as well as protein composition regarding their impact for future biomarker studies.Methods: Tear fluid was collected non-invasively from 18 healthy subjects performing Schirmer tests at four...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037811 | Pride
Mass spectrometry Tear fluid Schirmer test Tear flow rate  tear volume Protein concentration 
ProteomicsAmplified fluorogenic immunoassay for early diagnosis and monitoring of Alzheimer’s disease from tear fluid
Accurate diagnosis of Alzheimer’s disease (AD) in its earliest stage can prevent the disease and delay the onset of symptoms by maintaining a healthy lifestyle and controlling modifiable risk factors. Therefore, more sensitive, relatively inexpensive, non-invasive, and simple screening tools are req...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042142 | Pride
Alzheimer’s disease Immunoassay Magnetic nanoparticles Polymeric nanoprobes Tear fluid 
ProteomicsTear proteome of patients with non-infectious uveitis responders and non-responders to adalimumab
Proteomic anaysis of tear samples from patients with non-infectious uveitis responders and non-responders to adalimumab included in a cross-sectional study
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095892 | MassIVE
ProteomicsProteomic analysis of single tears from healthy human subjects
23 volunteers were recruited for this study. Tears were collected using microcapillary tubes (MCT). For each volunteer, a single tear sample was taken from one eye. For two of these volunteers, the procedure was performed in the morning (9-10 AM) and in the afternoon (5-6 PM) on the same day, once a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-06-25 | MSV000087703 | MassIVE
ProteomicsTear proteins altered in patients with persistent eye pain after refractive surgery: biomarker candidate discovery
Some patients develop persistent eye pain after refractive surgery, but the factors that cause or sustain pain are unknown. We tested whether tear proteins of patients with pain 3 months after surgery differ from patients without pain. Patients undergoing refractive surgery (LASIK or PRK) were recru...
ORGANISM(S): Homo sapiens (Human) 
2025-05-25 | PXD051071 | Pride
Corneal pain Eye pain Mass spectrometry Prk Human tears Lasik Quantitative proteomics Biomarker Tandem mass tags 
ProteomicsIdentification and validation of a tear fluid-derived protein biomarker signature in patients with Amyotrophic Lateral Sclerosis
The diagnosis of Amyotrophic Lateral Sclerosis (ALS) primarily relies on clinical findings and remains challenging, particularly in the early stages of the disease, where characteristic symptoms may be subtle and nonspecific. Therefore, the development of disease-specific and clinically validated bi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD062971 | Pride
Proteomics Diagnosis Amyotrophic lateral sclerosis Tear fluid Biomarker 
ProteomicsLectin-based affinity enrichment and characterization of N-glycoproteins from the human tear film by mass spectrometry
Glycosylation of proteins is one of the most common post-translational modification (PTM) and plays important regulatory functions in diverse biological processes such as protein stability or cell signaling. Accordingly, glycoproteins are also a consistent part of the human tear film proteome mainta...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2023-01-25 | PXD038280 | Pride
N-glycoproteins Mass spectrometry Pngase f Tear film Multi-lectin column 
ProteomicsProteomic Analysis of Tear Fluid from the Offspring of Keratoconus Patients Toward Novel Biomarkers and Pathways Associated with Corneal Biomechanical Weakness and Disease Susceptibility.
Keratoconus (KC) is a chronic and degenerative condition marked by pathological weakening, thinning, and protrusion of the corneal tissue. Corneal biomechanical weakness constitutes a hallmark of early keratoconus (KC) stages, which has underlined the importance of the study of biomechanical respons...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD049296 | Pride
Offspring Keratoconus Biomarkers Proteomics Tear fluid 
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