Sort   by:  
 Page size 
ProteomicsTIGAR Regulates Intestinal Mucus Barrier Integrity by Inhibiting Lactylation of G6PD/6PGD in Ulcerative Colitis
Oxidative stress and metabolic dysregulation in goblet cells represent significant contributors to the pathogenesis of ulcerative colitis (UC). TIGAR (TP53-induced glycolysis and apoptosis regulator) plays a critical role as a metabolic regulatory enzyme by promoting NADPH synthesis, thereby counter...
ORGANISM(S): Homo sapiens (Human) 
2026-01-29 | PXD069158 | Pride
Tigar  lactylation  6pgd  g6pd  ulcerative colitis 
ProteomicsTIGAR Regulates Intestinal Mucus Barrier Integrity by Inhibiting Lactylation of G6PD/6PGD in Ulcerative Colitis
Oxidative stress and metabolic dysregulation in goblet cells represent significant contributors to the pathogenesis of ulcerative colitis (UC). TIGAR (TP53-induced glycolysis and apoptosis regulator) plays a critical role as a metabolic regulatory enzyme by promoting NADPH synthesis, thereby counter...
ORGANISM(S): Homo Sapiens 
PXD069246 |
GenomicsBlocking 6PGD restricts immunosuppression driven by the innate immune response in cancer
Blocking 6PGD restricts immunosuppression driven by the innate immune response in cancer
PRJNA1168184 | ENA
UnknownDiscovery of Ebselen as an Inhibitor of 6PGD for Suppressing Tumor Growth.
Not available
S-EPMC7415460 | biostudies-literature
TranscriptomicsBlocking 6PGD restricts immunosuppression driven by the innate immune response in cancer
The pentose phosphate pathway (PPP) has always been relegated to the background of cellular metabolism, but our research identifies its unique and provocative influence on cell function, specifically in myeloid-derived suppressor cells (MDSCs). We’ve uncovered that 6-phosphogluconate dehydrogenase (...
ORGANISM(S): Mus musculus 
2025-11-12 | GSE278674 | GEO
TranscriptomicsA feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth
Alterations to the androgen receptor (AR) signalling axis and cellular metabolism are hallmarks of prostate cancer. This study provides insight into both hallmarks by uncovering a novel link between AR and the pentose phosphate pathway (PPP). Specifically, we identify 6-phosphogluoconate dehydrogena...
ORGANISM(S): Homo sapiens 
2020-10-01 | GSE152254 | GEO
GenomicsA feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth
A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth
PRJNA638813 | ENA
UnknownA feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth.
Not available
S-EPMC8416027 | biostudies-literature
Unknown6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function.
Not available
S-EPMC8553335 | biostudies-literature
ProteomicsPCNA regulates metabolism by stabilizing ENO1 and 6PGD
The essential roles of PCNA as a scaffold protein in DNA replication and repair are well established, while its more recently discovered cytosolic roles are less explored. Alpha-enolase (ENO1) and 6-phosphogluconate dehydrogenase (6PGD), important proteins in glycolysis and the Pentose Phosphate Pat...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028314 | Pride
Glycolysis Pi3k/akt pathway Cell signaling Apim-peptide Atx-101 Apim 
Sort   by:  
 Page size