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ProteomicsPCNA-targeting peptide modifies and increases the response to EGFR/HER2/VEGF inhibition in breast cancer cells
To combine inhibition of EGFR/HER2 and targeting of the cytosolic roles of PCNA using the APIM-peptide, and study the anti-cancer effects of this combinatory therapy in in vitro and in vivo breast cancer models.
ORGANISM(S): Mus musculus (Mouse) 
2020-01-15 | PXD011044 | Pride
Tnbc- triple negative breast cancer Pi3k- the phosphoinositide 3-kinase Her2/erbb2- human epidermal growth factor receptor 2 Signaling pathways Egfr- epidermal growth factor receptor Combination therapy Pcna- proliferating cell nuclear antigen Multi-targeting therapy Pr- progesterone receptor Mapk- mitogen-activated protein kinase Autophagy Vegf- vascular endothelial growth factor Er- estrogen receptor 
UnknownStructure of proliferating cell nuclear antigen (PCNA) bound to an APIM peptide reveals the universality of PCNA interaction.
Not available
S-EPMC5893992 | biostudies-literature
UnknownAPIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer.
Not available
S-EPMC5837745 | biostudies-literature
ProteomicsAPIM-peptide targeting PCNA improves cisplatin therapy in a rat muscle-invasive bladder cancer model
High mortality rate of muscle-invasive bladder cancer (MIBC) and complexity of disease demand new multi-targeting treatment strategies. Targeting proliferating cell nuclear antigen (PCNA) with a peptide containing the AlkB homologue 2 PCNA interacting motif (APIM), is shown to impair multiple vital ...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-09-10 | PXD008724 | Pride
Ay-27 Rat Mib Lfq Assay 
ProteomicsPCNA regulates metabolism by stabilizing ENO1 and 6PGD
The essential roles of PCNA as a scaffold protein in DNA replication and repair are well established, while its more recently discovered cytosolic roles are less explored. Alpha-enolase (ENO1) and 6-phosphogluconate dehydrogenase (6PGD), important proteins in glycolysis and the Pentose Phosphate Pat...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028314 | Pride
Glycolysis Pi3k/akt pathway Cell signaling Apim-peptide Atx-101 Apim 
TranscriptomicsAPIM treatment of different cancer cell lines, short and long term
Different cancer cell lines treated with the cell penetrating peptide APIM, alone and in combinatorial treatment with cytostatika. Low dose experiments over time, and higher dose over short time.
ORGANISM(S): Homo sapiens 
2018-07-29 | E-MTAB-5644 | biostudies-arrayexpress
TranscriptomicsA dual-mechanism antimicrobial peptide with antimutagenic activity targets the replisome and induces cell envelope stress
To combat the growing threat of multidrug-resistant bacteria, we need to develop novel antibiotics with unique modes of action. This study investigates the antibacterial properties of BTP-001 towards Escherichia coli. BTP-001 is a β-clamp targeting antimicrobial peptide containing an AlkB homologu 2...
ORGANISM(S): Escherichia coli 
2025-08-25 | GSE276254 | GEO
Unknown"Two hits - one stone"; increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling.
Not available
S-EPMC6126690 | biostudies-literature
UnknownNovel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo.
Not available
S-EPMC8009970 | biostudies-literature
UnknownAPIM-Mediated REV3L⁻PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells.
Not available
S-EPMC6337749 | biostudies-literature
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