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ProteomicsPCNA regulates metabolism by stabilizing ENO1 and 6PGD
The essential roles of PCNA as a scaffold protein in DNA replication and repair are well established, while its more recently discovered cytosolic roles are less explored. Alpha-enolase (ENO1) and 6-phosphogluconate dehydrogenase (6PGD), important proteins in glycolysis and the Pentose Phosphate Pat...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028314 | Pride
Glycolysis Pi3k/akt pathway Cell signaling Apim-peptide Atx-101 Apim 
UnknownEfficacy and Safety of ATX-101 by Treatment Session: Pooled Analysis of Data From the Phase 3 REFINE Trials.
Not available
S-EPMC6094350 | biostudies-literature
UnknownATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma.
Not available
S-EPMC8773508 | biostudies-literature
UnknownSubmental fat reduction using sequential treatment approach with cryolipolysis and ATX-101.
Not available
S-EPMC9325515 | biostudies-literature
UnknownMultiple Myeloma Cells with Increased Proteasomal and ER Stress Are Hypersensitive to ATX-101, an Experimental Peptide Drug Targeting PCNA.
Not available
S-EPMC11640687 | biostudies-literature
TranscriptomicsMicroarray analysis of Du145, PC3 and LNCaP human prostate cancer cell lines
Study aimed at evaluating differences in Du145, PC3 and LNCaP human prostate cancer cells treated with ATX-101 and docetaxel for 24h.
ORGANISM(S): Homo sapiens 
2017-12-31 | E-MTAB-4858 | biostudies-arrayexpress
ProteomicsTargeting PCNA in a subgroup of Multiple Myeloma cells inhibits the glycolysis and pentose phosphate pathway
PCNA is an essential protein in all cells with multiple well-known function in DNA replication and DNA repair. Recently, PCNA was shown to be involved in regulation of cellular signalling and central carbon metabolism via stabilizing the metabolic enzymes ENO1 and 6PGD. Furthermore, ATX-101, a PCNA ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-25 | PXD033510 | Pride
Targeting Pentose phosphate pathway Tk Multiple myeloma Cells Glycolysis Mib assay Pcna 
ProteomicsTargeting PCNA in a subgroup of Multiple Myeloma cells inhibits the glycolysis and pentose phosphate pathway (batch TK9)
PCNA is an essential protein in all cells with multiple well-known function in DNA replication and DNA repair. Recently, PCNA was shown to be involved in regulation of cellular signalling and central carbon metabolism via stabilizing the metabolic enzymes ENO1 and 6PGD. Furthermore, ATX-101, a PCNA ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-25 | PXD033531 | Pride
Targeting Pentose phosphate pathway Tk Multiple myeloma Cells Glycolysis Mib assay Pcna 
UnknownATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study.
Not available
S-EPMC9918429 | biostudies-literature
UnknownAutotaxin is a novel target of microRNA-101-3p.
Not available
S-EPMC6443858 | biostudies-literature
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