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ProteomicsPCNA-targeting peptide modifies and increases the response to EGFR/HER2/VEGF inhibition in breast cancer cells
To combine inhibition of EGFR/HER2 and targeting of the cytosolic roles of PCNA using the APIM-peptide, and study the anti-cancer effects of this combinatory therapy in in vitro and in vivo breast cancer models.
ORGANISM(S): Mus musculus (Mouse) 
2020-01-15 | PXD011044 | Pride
Tnbc- triple negative breast cancer Pi3k- the phosphoinositide 3-kinase Her2/erbb2- human epidermal growth factor receptor 2 Signaling pathways Egfr- epidermal growth factor receptor Combination therapy Pcna- proliferating cell nuclear antigen Multi-targeting therapy Pr- progesterone receptor Mapk- mitogen-activated protein kinase Autophagy Vegf- vascular endothelial growth factor Er- estrogen receptor 
TranscriptomicsAPIM treatment of different cancer cell lines, short and long term
Different cancer cell lines treated with the cell penetrating peptide APIM, alone and in combinatorial treatment with cytostatika. Low dose experiments over time, and higher dose over short time.
ORGANISM(S): Homo sapiens 
2018-07-29 | E-MTAB-5644 | biostudies-arrayexpress
UnknownPeptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis.
Not available
S-EPMC7261172 | biostudies-literature
UnknownAPIM-Mediated REV3L⁻PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells.
Not available
S-EPMC6337749 | biostudies-literature
UnknownStructure of proliferating cell nuclear antigen (PCNA) bound to an APIM peptide reveals the universality of PCNA interaction.
Not available
S-EPMC5893992 | biostudies-literature
UnknownAPIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer.
Not available
S-EPMC5837745 | biostudies-literature
ProteomicsPCNA regulates metabolism by stabilizing ENO1 and 6PGD
The essential roles of PCNA as a scaffold protein in DNA replication and repair are well established, while its more recently discovered cytosolic roles are less explored. Alpha-enolase (ENO1) and 6-phosphogluconate dehydrogenase (6PGD), important proteins in glycolysis and the Pentose Phosphate Pat...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028314 | Pride
Glycolysis Pi3k/akt pathway Cell signaling Apim-peptide Atx-101 Apim 
ProteomicsAPIM-peptide targeting PCNA improves cisplatin therapy in a rat muscle-invasive bladder cancer model
High mortality rate of muscle-invasive bladder cancer (MIBC) and complexity of disease demand new multi-targeting treatment strategies. Targeting proliferating cell nuclear antigen (PCNA) with a peptide containing the AlkB homologue 2 PCNA interacting motif (APIM), is shown to impair multiple vital ...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-09-10 | PXD008724 | Pride
Ay-27 Rat Mib Lfq Assay 
ProteomicsAOH1996, a small molecule ligand of PCNA, modulates PCNA interaction with RPB1
Targeting transcription replication conflicts, a major source of endogenous DNA double stranded breaks and genomic instability, could have important therapeutic implications. When transcription and DNA replication machineries encounter each other on chromosomes, one way to resolve the conflict is te...
ORGANISM(S): Homo sapiens (Human) 
2023-08-03 | PXD027782 | Pride
Apim motif Pcna Rpb1 Aoh1996 And transcription-replication conflict 
UnknownATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma.
Not available
S-EPMC8773508 | biostudies-literature
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