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MetabolomicsMechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation

Mechanical force is critical for the development and remodeling of bone. Here we report that mechanical force regulates the production of the metabolite asymmetric dimethylarginine (ADMA) via regulating the hydrolytic enzyme dimethylarginine dimethylaminohydrolase 1 (Ddah1) expression in osteobla...

2021-11-23 | MTBLS3725 | MetaboLights
MetabolomicsSpontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters
Not available
ORGANISM(S): Homo sapiens 
ST001860 | MetabolomicsWorkbench
MetabolomicsLC-MS-based isotope tracing data supporting cholesterol- and EA2-regulated fatty acid synthesis and tumor metabolic remodeling
This study contains LC-MS-based stable isotope tracing data investigating cholesterol- and EA2-regulated tumor metabolic remodeling. The dataset includes U-13C-glucose tracing in tumor cells and D2O tracing in animal models, supporting analysis of cholesterol-driven metabolic remodeling and the supp...
2026-10-03 | MTBLS14937 | MetaboLights
Proteomicsfull length protein sequencing method based on less specific and unspecific hydrolysis strategies 2
We describe a new strategy for LC-MS/MS based full length protein sequencing. Protein samples were unspecific hydrolyzed by three different methods(proteinase K, papain and microwave-assisted acid hydrolysis) to improve overlapping degree of peptides. After LC-MS/MS analysis, peptide sequences were ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Equus caballus (Horse) 
2022-02-15 | PXD030203 | Pride
Unspecific hydrolysis Protein sequencing De novo Maah Lc-ms/ms 
ProteomicsPeptide and MUC5B hydrolysis by the Mucin Degrading Protease (MdpL) from Limosilactobacillus fermentum
MUC5B is the predominant glycoprotein in saliva and is instrumental in the establishment and maintenance of multi-species eubiotic biofilms in the oral cavity. Investigations of the aciduric Lactobacillaceae family, and its role in biofilms emphasizes the diversity across different genera of the pro...
ORGANISM(S): Homo sapiens (Human) 
2023-03-22 | PXD039681 | Pride
Iob Mdpl Limosilactobacillus fermentum Muc5b Neuromedin Mog Lc-msms 
UnknownBoric acid catalysed hydrolysis of peroxyacids.
Not available
S-EPMC10103745 | biostudies-literature
GenomicsBacteria l Diversity Analysis and Evaluation Proteins Hydrolysis During the Acid Whey and Fish Waste Fermentation
Bacteria l Diversity Analysis and Evaluation Proteins Hydrolysis During the Acid Whey and Fish Waste Fermentation Raw sequence reads
PRJNA689220 | ENA
MetabolomicsWhat CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines

Background: Cell line specific, genome-scale metabolic models enable rigorous and systematic in silico investigation of cellular metabolism. Such models have recently become available for Chinese hamster ovary (CHO) too. However, a key ingredient, namely an experimentally validat...

2020-07-13 | MTBLS1210 | MetaboLights
ProteomicsProteomics data for - Unravelling the mechanism of selective protein hydrolysis by metal-organic frameworks
Metal-organic frameworks (MOFs) are emerging as alternatives to enzymes for selective peptide bond cleavage, which is a crucial procedure in proteomics, protein engineering, and proteolytic drug design. However, the limited understanding behind MOF-assisted protein interactions and hydrolysis mechan...
ORGANISM(S): Bos taurus (Bovine) 
2026-04-09 | PXD065039 | Pride
Cleavage Hydrolysis Lc-ms Protein Mofs Uio-66 
UnknownAcid hydrolysis of saponins extracted in tincture.
Not available
S-EPMC7774937 | biostudies-literature
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