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ProteomicsProteomic changes in human sperm during sequential in vitro capacitation and acrosome reaction.
The male gamete is not completely mature after ejaculation and requires further events in the female genital tract to acquire fertilizing ability, including the processes of capacitation and acrosome reaction. In order to shed light on dynamic protein changes experienced by the sperm cell in prepara...
ORGANISM(S): Homo sapiens (Human) 
2019-12-17 | PXD014871 | Pride
Acrosome reaction Proteomics Mass spectrometry Tmt labeling Sperm Capacitation Spermatozoa 
OtherFunctional Amyloids in the Mouse Sperm Acrosome.
Data from ProteomeXchange, PXD ID: PXD000592. File: 130614_CornwallG_GB_GC3_HILIC.mzML. Published as part of Mol Cell Biol. 2014 May 5 . From the Abstract: {{i}} The acrosomal matrix (AM) is an insoluble structure within the sperm acrosome that serves as a scaffold controlling the release of AM ass...
ORGANISM(S): Abelson_murine_leukemia_virus_uid14654,ectromelia_virus_uid14211,minute_virus_of_mice_uid14019,moloney_murine_leukemia_virus_uid15030,moloney_murine_sarcoma_virus_uid14721,mouse_mammary_tumor_virus_uid14435,mouse_parvovirus_1_uid14325,mouse_parvovirus_2_uid17125,mouse_parvovirus_3_uid17123,mouse_parvovirus_4a_uid33009,mouse_parvovirus_5a_uid33007,murid_herpesvirus_1_uid15181,murid_herpesvirus_2_uid14419,murid_herpesvirus_4_uid14458,murine_adenovirus_3_uid37713,murine_adenovirus_a_uid14519,murine_hepatitis_virus_a59_uid15350,murine_hepatitis_virus_jhm_uid15138,murine_norovirus_1_uid17577,murine_osteosarcoma_virus_uid14655,murine_pneumotropic_virus_uid14071,murine_polyomavirus_uid15489,murine_type_c_retrovirus_uid15204, Mouse 
GPM32310000037 | GPMDB
Resource Reanalysis 
ProteomicsProteomes of acrosomes and acrosome-reacted sperm of the house mouse
Using label-free nano-scale liquid chromatography tandem mass spectrometry (nLC-MS2) proteomics, we provide proteomes of the acrosomes and acrosome-reacted sperm isolated from cauda epididymis of free-living house mice Mus musculus musculus. Among all proteins, 334 proteins were significantly enrich...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-27 | PXD039128 | Pride
Mus musculus Acrosome Label free 
ProteomicsLoss of Cep70 function affects acrosome biogenesis and flagella formation during spermiogenesis
The spermatogenesis process is complex and delicate, and any error in any step may cause spermatogenesis arrested and even male infertility. Through mutation screening of patients with clinical azoospermia, we found a heterozygous site of the same mutation on CEP70. The centrosome protein 70 (Cep70)...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD023680 | Pride
Cep70  male infertility  acrosome biogenesis  flagella formation  spermiogenesis 
TranscriptomicsMAEL-dependent selective processing of pachytene piRNA precursors and translation of spermiogenic mRNAs
Piwi-interacting small RNAs (piRNAs) of fetal prospermatogonia of mice have been strongly implicated in transposon control. In contrast, little is known about biogenesis and function of abundant piRNAs from adult testes expressed in late spermatocytes and round spermatids. These so-called "pach...
ORGANISM(S): Mus musculus 
2014-07-25 | E-GEOD-50983 | biostudies-arrayexpress
ProteomicsPFN4 is required for acrosome biogenesis by regulating autophagy through PI3K/AKT/mTOR pathway
We generated Pfn4 knockout mice and showed that male mice are infertile and acrosome biogenesis is impaired from first phase of Development (Golgi-phase). Autophagy participates in acrosome formation and LC-MS data showed proteins related to autophagy, PI3K/AKT signaling and mTOR are enriched in PFN...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-15 | PXD030394 | Pride
Infertility Autophagy Lc-ms Mouse Profilin 4 
GenomicsLoss of Profilin3 impairs spermiogenesis by affecting acrosome biogenesis, autophagy, manchette development and mitochondrial organization
Loss of Profilin3 impairs spermiogenesis by affecting acrosome biogenesis, autophagy, manchette development and mitochondrial organization
PRJNA718299 | ENA
UnknownMechanism of Acrosome Biogenesis in Mammals.
Not available
S-EPMC6759486 | biostudies-literature
GenomicsBRD4 dynamics reveal novel acrosome-dependent chromatin reorganization during post-meiotic mammalian sperm development
During the post-meiotic phase of spermatogenesis, transcription is progressively repressed as the nuclei of haploid spermatids are compacted through a dramatic chromatin reorganization involving hyper-acetylation and replacement of most histones with sperm-specific protamines. Although BRDT has been...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-56526 | biostudies-arrayexpress
GenomicsBRD4 dynamics reveal novel acrosome-dependent chromatin reorganization during post-meiotic mammalian sperm development
During the post-meiotic phase of spermatogenesis, transcription is progressively repressed as the nuclei of haploid spermatids are compacted through a dramatic chromatin reorganization involving hyper-acetylation and replacement of most histones with sperm-specific protamines. Although BRDT has been...
ORGANISM(S): Mus musculus 
2015-03-06 | GSE56526 | GEO
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