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ProteomicsInteractome analysis reveals a link of the novel ALMS1-CEP70 complex to centrosomal clusters
Alström syndrome (ALMS) is a very rare autosomal-recessive disorder, causing a broad range of clinical defects most notably retinal degeneration, type 2 diabetes and truncal obesity. The ALMS1 gene codes for a ~0.5 MDa protein, which has hampered analysis in the past. Interestingly, ALMS1 has been s...
ORGANISM(S): Homo sapiens (Human) 
2024-01-25 | PXD046401 | Pride
Cilia Centrosome Basal body Ciliopathy Alström syndrome Crispr/cas9 Protein complex analysis 
ProteomicsLoss of Cep70 function affects acrosome biogenesis and flagella formation during spermiogenesis
The spermatogenesis process is complex and delicate, and any error in any step may cause spermatogenesis arrested and even male infertility. Through mutation screening of patients with clinical azoospermia, we found a heterozygous site of the same mutation on CEP70. The centrosome protein 70 (Cep70)...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD023680 | Pride
Cep70  male infertility  acrosome biogenesis  flagella formation  spermiogenesis 
UnknownA role for Cep70 in centriole amplification in multiciliated cells.
Not available
S-EPMC7856201 | biostudies-literature
UnknownLoss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis.
Not available
S-EPMC8116340 | biostudies-literature
UnknownIdentification of biallelic variations of CEP70 in patients with male infertility.
Not available
S-EPMC10035576 | biostudies-literature
UnknownInteractome Analysis Reveals a Link of the Novel ALMS1-CEP70 Complex to Centrosomal Clusters.
Not available
S-EPMC10820798 | biostudies-literature
UnknownCEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly.
Not available
S-EPMC3190865 | biostudies-literature
UnknownCYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.
Not available
S-EPMC4220159 | biostudies-literature
TranscriptomicsThe cutaneous response to a mosquito bite at different diurnal time point
Examination of the transcriptional changes occurring in the skin upon mosquito bite at different times of day. Approximately 20 A. aegypti mosquitoes were allowed to bite mice on the ear at two timepoints, zeitgeber time (ZT)1 and ZT11, corresponding to dawn and dusk, respectively. Twenty-four hours...
ORGANISM(S): Mus musculus 
2025-09-16 | E-MTAB-15581 | biostudies-arrayexpress
UnknownVerification of prognostic expression biomarkers is improved by examining enriched leukemic blasts rather than mononuclear cells from acute myeloid leukemia patients.
Not available
S-EPMC10022072 | biostudies-literature
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