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ProteomicsLoss of Cep70 function affects acrosome biogenesis and flagella formation during spermiogenesis
The spermatogenesis process is complex and delicate, and any error in any step may cause spermatogenesis arrested and even male infertility. Through mutation screening of patients with clinical azoospermia, we found a heterozygous site of the same mutation on CEP70. The centrosome protein 70 (Cep70)...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD023680 | Pride
Cep70  male infertility  acrosome biogenesis  flagella formation  spermiogenesis 
ProteomicsPFN4 is required for acrosome biogenesis by regulating autophagy through PI3K/AKT/mTOR pathway
We generated Pfn4 knockout mice and showed that male mice are infertile and acrosome biogenesis is impaired from first phase of Development (Golgi-phase). Autophagy participates in acrosome formation and LC-MS data showed proteins related to autophagy, PI3K/AKT signaling and mTOR are enriched in PFN...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-15 | PXD030394 | Pride
Infertility Autophagy Lc-ms Mouse Profilin 4 
UnknownMechanism of Acrosome Biogenesis in Mammals.
Not available
S-EPMC6759486 | biostudies-literature
GenomicsLoss of Profilin3 impairs spermiogenesis by affecting acrosome biogenesis, autophagy, manchette development and mitochondrial organization
Loss of Profilin3 impairs spermiogenesis by affecting acrosome biogenesis, autophagy, manchette development and mitochondrial organization
PRJNA718299 | ENA
UnknownAtg7 is required for acrosome biogenesis during spermatogenesis in mice.
Not available
S-EPMC4085765 | biostudies-literature
UnknownThe Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice.
Not available
S-EPMC10065795 | biostudies-literature
UnknownTMC7 deficiency causes acrosome biogenesis defects and male infertility in mice.
Not available
S-EPMC11398861 | biostudies-literature
UnknownELAPOR1 is a copper-dependent tethering factor driving proacrosomal vesicle fusion during acrosome biogenesis.
Not available
S-EPMC12337314 | biostudies-literature
UnknownExpression of Flotilin-2 and Acrosome Biogenesis Are Regulated by MiR-124 during Spermatogenesis.
Not available
S-EPMC4551675 | biostudies-literature
UnknownFAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in mice.
Not available
S-EPMC8627553 | biostudies-literature
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