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MetabolomicsActivation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure

Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy metabolism remain ill-defined. Here we identi...

2026-01-28 | MTBLS13783 | MetaboLights
MetabolomicsGut microflora alleviate immune response during E.coli-induced bladder cystits via AhR/MANF activation

In recent years, with the deepening of research on intestinal microbiota, we found intestinal microbiota plays an important role in host immune regulation and barrier maintenance through cross-talk between the microbiota and the host. New evidence suggests that disruption of the fragile balance w...

2023-07-11 | MTBLS5572 | MetaboLights
MetabolomicsBisphenol mixture-induced DGKB downregulation promotes premature human neurogenesis through the activation of MAPK pathway

The widespread industrial transition from bisphenol A (BPA) to structural analogs such as BPS, BPE, and BPAF has raised significant concerns regarding their potential health risks. However, their neurodevelopmental risks and underlying molecular mechanisms, particularly when present as complex m...

2026-09-29 | MTBLS15671 | MetaboLights
ProteomicsLF2 phosphorylation of the CDKL5 activation loop controls CDKL5’s activity
Cdkl5 Deficiency Disorder (CDD) is caused by variants in the protein kinase CDKL5, leading to symptoms such as seizures, developmental delay, and severe intellectual disability. The Chlamydomonas homologue of human CDKL5 is the flagellar protein LF5, whose absence results in a long flagella phenotyp...
ORGANISM(S): Chlamydomonas reinhardtii 
2025-11-15 | PXD068782 | Pride
Cilia Cdkl5 Phospho-proteome Flagella Cdd Chlamydomonas Cdk20 Lf5 Activation loop Lf2 Phosphorylation Kinase Proteome Cdkl5 deficiency disorder 
ProteomicsActivation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation
Pyk2 is a multidomain non-receptor tyrosine kinase that undergoes a complex, multi-stage activation process. Ca2+-flux induces conformational rearrangements that relieve autoinhibitory FERM domain interactions. The kinase domain phosphorylates a key linker residue to recruit Src kinase. Pyk2 and Src...
ORGANISM(S): Homo sapiens (Human) 
2023-03-08 | PXD034028 | Pride
Kinase Phosphorylation Hdx-ms 
MetabolomicsMetabolomic changes in Mycobacterium avium subsp. paratuberculosis (MAP) challenged Holstein-Friesian cattle suggest the role of serum amino acids as indicators of immune system activation

INTRODUCTION: Paratuberculosis, commonly known as Johne’s disease, is a chronic intestinal infection of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP). Clinical signs, including reduced milk yields, weight loss and diarrhoea, are typically abse...

2022-02-23 | MTBLS2963 | MetaboLights
ProteomicsStructural basis of T-loop-independent recognition and activation of CDKs by the CDK-activating kinase
Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalysing the activating phosphorylation of CDKs on a conserved threonine residue within the regulatory T-loop. However, structural data illum...
ORGANISM(S): Homo sapiens (Human) 
2025-10-16 | PXD068021 | Pride
T-loop-independent recognition Cdk-activating kinase 
ProteomicsLF2 phosphorylation of the CDKL5 activation loop controls CDKL5’s activity
Cdkl5 Deficiency Disorder (CDD) is caused by variants in the protein kinase CDKL5, leading to symptoms such as seizures, developmental delay, and severe intellectual disability. The Chlamydomonas homologue of human CDKL5 is the flagellar protein LF5, whose absence results in a long flagella phenotyp...
ORGANISM(S): Chlamydomonas reinhardtii 
2025-11-15 | PXD066796 | Pride
Cilia Cdkl5 Phospho-proteome Flagella Cdd Chlamydomonas Cdk20 Lf5 Activation loop Lf2 Phosphorylation Kinase Proteome Cdkl5 deficiency disorder 
GenomicsLoop extrusion dynamics and cooperative activation independently regulate enhancer-driven transcription
Loop extrusion dynamics and cooperative activation independently regulate enhancer-driven transcription
PRJNA1460714 | ENA
TranscriptomicsRole of LDB1 in the transition from chromatin looping to transcription activation
Many questions remain about how close association of genes and distant enhancers occurs and how this is linked to transcription activation. In erythroid cells, LDB1 is recruited to the β-globin locus via LMO2 and is required for looping of the β-globin locus control region (LCR) to the active β-glob...
ORGANISM(S): Mus musculus 
2014-07-02 | E-GEOD-54549 | biostudies-arrayexpress
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