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ProteomicsKinetochores read detyrosinated tubulin to sustain microtubule attachments
Post-translational cycles of α-tubulin detyrosination/tyrosination generate microtubule diversity, with broad physiological and clinical implications. However, the mechanistic understanding of how this microtubule diversity is decoded into specific cellular functions remains largely unknown. Here we...
ORGANISM(S): Homo sapiens (Human) 
2024-10-03 | PXD047133 | Pride
Kinetochore microtubule attachments Tubulin detyrosination/tyrosination code Kmn complex 
ProteomicsChemical proteomics reveals protein tyrosination extends beyond the alpha-tubulins in human cells.
Tubulin detyrosination-tyrosination cycle regulates the stability of microtubules. Thus far described on α-tubulins, the tyrosination level is maintained by a single tubulin-tyrosine ligase (TTL). However, the precise dynamics and tubulin isoforms which undergo (de)tyrosination in neurons are unknow...
ORGANISM(S): Homo sapiens (Human) 
2022-10-20 | PXD037402 | Pride
Ingns Dia-nn Tyrosination Sp2e Sh-sy5y 
Unknownα-tubulin detyrosination fine-tunes kinetochore-microtubule attachments.
Not available
S-EPMC11550433 | biostudies-literature
UnknownCrosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer's disease.
Not available
S-EPMC9459041 | biostudies-literature
UnknownThe role of α-tubulin tyrosination in controlling the structure and function of hippocampal neurons.
Not available
S-EPMC9627282 | biostudies-literature
UnknownChemical Proteomics Reveals Protein Tyrosination Extends Beyond the Alpha-Tubulins in Human Cells.
Not available
S-EPMC10099736 | biostudies-literature
UnknownTubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.
Not available
S-EPMC9337816 | biostudies-literature
UnknownStructural basis of tubulin detyrosination by VASH2/SVBP heterodimer.
Not available
S-EPMC6642083 | biostudies-literature
UnknownEffects of microtubule (de)tyrosination on the morphology and motility of Trypanosoma brucei and cross-talk with polyglutamylation.
Not available
S-EPMC12714142 | biostudies-literature
UnknownStructural basis of tubulin detyrosination by vasohibins.
Not available
S-EPMC6609488 | biostudies-literature
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