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MetabolomicsOxygen-induced pathological angiogenesis promotes intense lipid synthesis and remodeling in the retina

The retina is a notable tissue with high metabolic needs which relies on specialized vascular networks to protect the neural retina while maintaining constant supplies of oxygen, nutrients and dietary essential fatty acids. Here we analyzed the lipidome of the mouse retina under healthy and patho...

2023-05-09 | MTBLS6965 | MetaboLights
TranscriptomicsRegulation of Angiogenesis by EZH2
While VEGF-targeted therapies are showing promise in clinical studies, new angiogenesis targets are needed to make additional gains. Here, we show that increased Zeste homologue 2 (EZH2) expression in either tumor cells or in tumor vasculature is predictive of poor clinical outcome. The increase in ...
ORGANISM(S): Homo sapiens 
2010-10-12 | E-GEOD-20381 | biostudies-arrayexpress
ProteomicsAnimal-free three-dimensional in vitro angiogenesis tool
All metabolically active tissues have a dense vascular network to supply oxygen and nutrients. Angiogenesis, the formation of new blood vessels from existing ones, can be activated by the lack of oxygen in cells, disease, trauma, or tumor growth. Due to its essential role in cell survival, angiogene...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD077881 | Pride
Human Capillary-like formation In vitro 3d cell model Animal-free Angiogenesis Nanofibrillated cellulose hydrogel Coculture 
TranscriptomicsTranscription profiling of rat cirrhotic liver treated with angiogenesis inhibitors
Background and aims: There are considerable evidences demonstrating that angiogenesis and chronic inflammation are mutually dependent. However, although cirrhosis progression is characterized with a chronic hepatic inflammatory process, this connection is not sufficiently explored as a therapeutic s...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-6929 | biostudies-arrayexpress
ModelsYang2012 - cancer growth with angiogenesis
The paper describes a model of tumor growth with angiogenesis. Created by COPASI 4.26 (Build 213) This model is described in the article: Mathematical modeling of solid cancer growth with angiogenesis Hyun M Yang Theoretical Biology and Medical Modelling 2012, 9:2 Abstract: Background: Cance...
2024-09-02 | BIOMD0000000796 | BioModels
UnknownPathological angiogenesis: mechanisms and therapeutic strategies.
Not available
S-EPMC10105163 | biostudies-literature
UnknownEndothelial USP8 is essential for angiogenesis.
Not available
S-EPMC12852293 | biostudies-literature
UnknownEndothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle.
Not available
S-EPMC3822003 | biostudies-literature
TranscriptomicsMGMT modulates glioblastoma angiogenesis and response to the tyrosine kinase inhibitor sunitinib
Angiogenesis inhibitors, such as sunitinib, represent a promising strategy to improve glioblastoma (GBM) tumor response. In this study, we used the O6-methylguanine methyltransferase (MGMT)-negative GBM cell line U87MG stably transfected with MGMT (U87/MGMT) to assess whether MGMT expression affects...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-40776 | biostudies-arrayexpress
TranscriptomicsAngiogenesis gene expression upon Notch activation in human vascular smooth muscle cells
VSMCs were cultured on Jag1 or IgG-coated plates as described above. RNA was extracted using RNA isolation kit (Qiagen). Reverse-transcription PCR was done with RNA-to-cDNA kit (Applied Biosystems). cDNA was run on a TaqMan Low-Density Array, human angiogenesis panel (Applied Biosystems , Cat#437872...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-34024 | biostudies-arrayexpress
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