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MetabolomicsExercise-generated β-aminoisobutyric acid (BAIBA) reduces cardiomyocytes metabolic stress and apoptosis caused by mitochondrial dysfunction through the miR-208b/AMPK pathway

OBJECTIVE: To explore the cardioprotective effects of exercise-derived β-aminoisobutyric (BAIBA) on cardiomyocyte apoptosis and energy metabolism in a rat model of heart failure (HF).

METHODS: In male Sprague-Dawley rats (8-week-old), myocardial infarction ...

2022-03-08 | MTBLS3927 | MetaboLights
TranscriptomicsTranscription profiling of human embryonic kidney cells expressing apoptosis inducing proteins, time series
Three apoptosis inducing proteins, ACO1, STK3 and XBP1 were discovered in a previous reverse transfection screen. HEK293T cells were harvested and RNA extracted from the cells after over-expression of these 3 proteins at 12, 24 and 48 hours. A positive apoptosis inducer staurosporine and a negative ...
ORGANISM(S): Homo sapiens 
2005-09-05 | E-MEXP-421 | biostudies-arrayexpress
ProteomicsProteomic profiling of colorectal cancer cell culture samples treated with apoptosis- and mTOR inhibitors under normoxia and hypoxia
To examine changes in tyrosine kinase activity in colorectal cancer cell culture samples treated with apoptosis inhibitors or/and mTOR inhibitors, under normoxic or/and hypoxic experimental conditions.
ORGANISM(S): Homo sapiens 
2016-06-15 | E-MTAB-3870 | biostudies-arrayexpress
TranscriptomicsDeterminants of sensitivity to DZNep induced apoptosis in multiple myeloma cells
The 3-Deazaneplanocin A (DZNep), one of S-adenosylhomocysteine (AdoHcy) hydrolase inhibitors, has shown antitumor activities in a broad range of solid tumors and acute myeloid leukemia. Here, we examined its effects on multiple myeloma (MM) cells and found that, at 500 nM, it potently inhibited grow...
ORGANISM(S): Homo sapiens 
2011-07-04 | E-GEOD-26921 | biostudies-arrayexpress
TranscriptomicsEstrogen receptor prevents p53-dependent apoptosis in breast cancer
More than two thirds of breast cancers express the estrogen receptor (ER) and depend on estrogen for growth and survival. Therapies targeting ER function including aromatase inhibitors that block the production of estrogens and ER antagonists that alter ER transcriptional activity play a central rol...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-39870 | biostudies-arrayexpress
TranscriptomicsRole of Apollon in human melanoma resistance to anti-tumor agents that activate the intrinsic or the extrinsic apoptosis pathways
PURPOSE: To assess the role of Apollon in melanoma resistance to intrinsic and extrinsic pathways of apoptosis and to identify strategies to reduce its expression. EXPERIMENTAL DESIGN: Expression of Apollon was assessed in melanoma cell lines and in surgical specimens.Gene expression profiling, m...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-34686 | biostudies-arrayexpress
TranscriptomicsEffective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate
We investigated the ability of HDAC inhibitors (HDACi) to target CML stem cells. Treatment with HDACi combined with IM effectively induced apoptosis in quiescent CML progenitors resistant to elimination by IM alone, and eliminated CML stem cells capable of engrafting immunodeficient mice. In vivo ad...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-20876 | biostudies-arrayexpress
ProteomicsT-type calcium channel inhibitors induce apoptosis in medulloblastoma cells associated with altered metabolic activity
Medulloblastoma (MB) is the most common malignant paediatric brain tumour. In our previous studies, we developed a novel 3D assay for MB cells and screened of plasma membrane calcium channel modulators. These studies identified T-type (CaV3) channel inhibitors, mibefradil and NNC-55-0396 (NNC) as se...
ORGANISM(S): Homo sapiens (Human) 
2023-04-27 | PXD026988 | Pride
Proteomics Medulloblastoma Cav3 inhibitors Calcium channels Apoptosis Therapy 
TranscriptomicsThe gamma secretase inhibitor LLNle induces apoptosis of human GBM tumor initiating cells
Glioblastomas (GBM) are poorly differentiated astrocytic tumors arising in the Central Nervous System (CNS), which despite aggressive treatments are still characterized by a fatal outcome. Several studies have shown the existence of a subpopulation of cells within glioma tumors displaying cancer ste...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14581 | biostudies-arrayexpress
ProteomicsRepurposing BCL2 inhibitors: Venetoclax protects against acinar cell necrosis in acute pancreatitis by promoting apoptosis
Acute pancreatitis (AP), a severe inflammatory disorder of the pancreas, lacks effective pharmacological treatment. The disease is primarily driven by necrosis of pancreatic acinar cells (PACs), which intensifies inflammation and organ injury. This study explores the potential of BCL2 inhibitors, sp...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD064881 | Pride
Pancreas Bcl2 inhibitors Venetoclax Pancreatitis Abt-199 Calcium signaling Fibrosis Abt-263 Necrosis Navitoclax Apoptosis 
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