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MetabolomicsMacrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, ...
2021-03-05 | MTBLS2159 | MetaboLights
TranscriptomicsATP effect on Arabidopsis roots
Extracellular adenosine 5’-triphosphate (ATP) is a signaling molecule. To define the global transcriptional response to ATP, we performed DNA microarray analysis using RNA derived from wild-type (Col-0) Arabidopsis and the dorn1-1 mutant, Lectin receptor kinase I.9 (At5g60300) carrying a EMS point m...
ORGANISM(S): Arabidopsis thaliana 
2014-01-27 | E-GEOD-52610 | biostudies-arrayexpress
ProteomicsThe inhibitor protein IF1 from mammalian mitochondria inhibits ATP hydrolysis but not ATP synthesis by the ATP synthase complex
The hydrolytic activity of the ATP synthase in bovine mitochondria is inhibited by a protein called IF1, but bovine IF1 has no effect on the synthetic activity of the bovine enzyme in mitochondrial vesicles in the presence of a proton motive force. As part of an investigation into the inhibitory eff...
ORGANISM(S): Bos taurus (Bovine) 
2024-01-29 | PXD045079 | Pride
Bovine mitochondria Atp synthase If1 protein Absolute quantification 
MetabolomicsPFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

Aerobic glycolysis, termed the Warburg effect, is one of the aberrant metabolic pathways in highly proliferating cells. Glycolysis provides glycolytic metabolites to support the generation of biomass, such as nucleotides, amino acids, and lipids. To date, research on the direct interactions betwe...

2025-07-08 | MTBLS12688 | MetaboLights
MetabolomicsGDF15 hijacks B cells to fuel the lifeblood of tumor salvage pyrimidine synthesis
B cell-tumor crosstalk has emerged as a critical determinant of tumor progression; however, its role in metabolic reprogramming and therapeutic resistance remains poorly understood. Here, we uncover a metabolic feedback loop that drives resistance to dihydroorotate dehydrogenase (DHODH) inhibitors. ...
2026-09-27 | MTBLS15820 | MetaboLights
MetabolomicsSteady-state metabolomics Saccharomyces cerevisiae mitochondrial fatty acid synthesis (mtFAS) mutants and CTP1 overexpression
Not available
ORGANISM(S): Saccharomyces cerevisiae 
ST002232 | MetabolomicsWorkbench
MetabolomicsComparative metabolomics analysis of the key metabolic nodes in propionic acid synthesis in Propionibacterium acidipropionici
Not available
ORGANISM(S): Acidipropionibacterium acidipropionici 
ST000116 | MetabolomicsWorkbench
ProteomicsMTB_ATP-bindingProteome
Mycobacterium tuberculosis ATP-binding Proteome
ORGANISM(S): Mycobacterium Tuberculosis 
2013-12-31 | PAe004062 | PeptideAtlas
ProteomicsQuantitative phosphoproteome of ecto-ATP synthase blockade in lung cancer cells
ATP synthase is crucial for ATP synthesis in living cells. Recently, ATP synthase was found not only in mitochondria but also on the extracellular surface, named as ectopic ATP synthase (ecto-ATP synthase). ATP synthase inhibitor is a potential drug candidate to fight cancer by blocking the ecto-ATP...
ORGANISM(S): Homo sapiens (Human) 
2015-11-06 | PXD000696 | Pride
Lung cancer cells Phosphoproteome Ecto-atp synthase 
GenomicsYTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
PRJNA1040931 | ENA
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