azoospermia - OmicsDI

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Genomics (134)
Transcriptomics (91)
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Genomic (2)
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Methylation profiling (1)

Organisms

Homo sapiens (63)
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Aerococcus urinae NBRC 15544 = CCUG 36881 (13)
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Streptococcus dysgalactiae subsp. equisimilis SK1249 (13)
Drosophila melanogaster (6)
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Organisms

Homo sapiens (53)
Mus musculus (36)
Rattus norvegicus (1)

Repository

ENA (113)
geo (74)
biostudies-arrayexpress (35)
pride (13)
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dbGaP (2)
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NODE (2)
ExpressionAtlas (1)

Tissue

Testis (6)
Extracellular vesicle (2)
Seminal plasma (2)
Peripheral whole blood (1)
Testicle (1)
Cell culture (1)
Embryo (1)
Embryonic stem cell (1)
Peritubular myoid cell (1)

Disease

Non-obstructive azoospermia (2)
Azoospermia (2)
Azoospermia (2)
Oligoasthenoteratozoospermia (2)
Ejaculatory azoospermia (1)
Normal (1)
Obstructive azoospermia (1)
Oligospermia (1)
Male infertility (1)

Technology Type

Mass Spectrometry (13)
Shotgun proteomics (6)
Bottom-up proteomics (4)
ILLUMINA, Illumina HiSeq 2000 (2)
Mass spectrometry (2)
Data-dependent acquisition (2)
ILLUMINA, Illumina HiSeq 2500 (1)
Top-down proteomics (1)

Instrument Platform

Illumina HiSeq 2500 (2)
Illumina HiSeq 2000 (1)
Illumina HiSeq 4000 (1)
Orbitrap Fusion (1)
Q Exactive (1)
240-MS GC Ion Trap (Varian) (1)
Liquid Chromatography MS - negative - hilic (1)
Liquid Chromatography MS - positive - hilic (1)

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2012 (11)
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2008 (7)
2020 (6)
2022 (5)
2016 (4)
2015 (4)
2011 (4)
2010 (4)
2019 (3)
2007 (2)
2005 (1)
2004 (1)
2017 (1)

CHEBI ID

CHEBI:140611 (1)
CHEBI:175859 (1)
CHEBI:89105 (1)
CHEBI:186609 (1)
CHEBI:174625 (1)
CHEBI:187055 (1)
CHEBI:174976 (1)
CHEBI:175677 (1)
CHEBI:190179 (1)
CHEBI:89594 (1)
CHEBI:89533 (1)
CHEBI:192340 (1)
CHEBI:192033 (1)
CHEBI:176221 (1)
CHEBI:49007 (1)
CHEBI:179431 (1)
CHEBI:174191 (1)
CHEBI:67591 (1)
CHEBI:174376 (1)
CHEBI:84495 (1)
CHEBI:84816 (1)
CHEBI:44395 (1)
CHEBI:3689 (1)
CHEBI:38728 (1)
CHEBI:184296 (1)
CHEBI:169036 (1)
CHEBI:184138 (1)
CHEBI:174681 (1)
CHEBI:173801 (1)
CHEBI:190405 (1)

Metabolite Name

2-Pyrrolidineacetic acid (2)
1-Methyl-4-acetylaminomethyl-1,2,3,6-tetrahydropyridine (1)
(+/-)-2,2,4,7,7,9-Hexamethyl-1,6-dioxaspiro[4.4]nonane (1)
2,2,4,4,6,6-hexamethyl-1,3,5-Trithiane (1)
6,6-Dimethyl-(1S)-Bicyclo(3.1.1)hept-2-ene-2-methanol (1)
7-Chloro-1-{[3-(dimethylamino)propyl]imino}-1,3,4,10-tetrahydro-10-hydroxy (1)
1-Trimethylsilyloxy-2-trimethylsilylamino-3-(3′-methoxy-4″-trimethylsilyloxy (1)
Hexakis-O-(trimethylsilyl) Hexit-1,5-D2 (1)
1,2,3,4,5-pentakis-O-(trimethylsilyl)-L-Sorbopyranose (1)
[1,3-Di(4-pyridyl)propane] (Bis{bis[9-borabicyclo(3.3.1)nonan-9-yl]oxide}) (1)
1a,2,5,5a,6,9,10,10a–octahydro-5a-hydroxy-4-(hydroxymethyl)-1-Hexadecanoic acid (1)
1,5-didesoxy-tris-O-(trimethylsilyl) D2-pentitol-2,4 (1)
1,8-Dimethyl-3,6-diazahomoadamantan-9-ol (1)
8-aalpha-Benzyloxymethyl-7alpha-hydroxy-4alpha-methoxycarbonyl-3-OXO-4aalpha-6.7.8.A.tetrahydroisochromane (1)
3-benzyl-2-cyclohexyl-3-hydroxy-2,3-dihydroIsoindol-1-one (1)
3.8.11.Trimethyl-4.7.10-trioxo-6.9-dimethoxy-1.2.3.4.5.6.7.10.-octahydro-1.5-imino-3-benzazo-cine (1)
7-[2-(3-Hydroxyoctyl)-5-hydroxy-3-oxo-cyclopentyl]heptanoic acid (1)
N-propoxycarbonyl-L-phenylalanine pentyl ester (1)
6-Methoxy-4-methylquinazolin-2-ylsulfanyl)acetic acid ethyl ester (1)
2-(1,3-Dioxo-1,3-dihydroisoindol-2-yl)-3-hydroxypropanoic acid (1)
Phthaloylaspartic acid (1)
5,6-dihydro-3-(3,4-dimethoxyphenyl)-4,6,6-trimethyl Pyridin-2(1H)-one (1)
1-[5-nitro-2-(1-piperidyl)benzylideno]amino guanidine (1)
1-Methyl-trans-decahydroquinol-5(equat)-ol (1)
N′-[2-(ethyl)Butylamino-5-nitrobenzylidine] (1)
1-cyano-1-(1-cyclopenten-3-one-1-yl)-acetic acid ethyl ester (1)
Beta,4-dimethyl-3-Cyclohexene-1-ethanol (1)
Tricyclo[4.3.1.13,8]undecan-1-amine (1)
Decahydroquinol-5(equat)-ol (1)
1,4,13-trioxa-7,10,16,19-tetraazacycloheneicosane-6,9,17,20-tetrone (1)

First Public Date

2024 (19)
2023 (15)
2014 (15)
2026 (12)
2025 (11)
2021 (9)
2020 (8)
2018 (8)
2022 (6)
2017 (4)
2019 (3)
2016 (3)

Study type

Transcription profiling by array (25)
RNA-seq of coding RNA (4)
Comparative genomic hybridization by array (2)
Transcription profiling by SAGE (1)
Human - High-throughput sequencing (1)
Methylation profiling by array (1)
RNA-seq of non coding RNA (1)

Release Date

2022 (105)
2021 (91)
2025 (85)
2023 (79)
2020 (56)
2024 (51)
2019 (46)
2016 (36)
2018 (32)
2017 (31)
2015 (23)
2014 (22)
2013 (20)
2012 (19)
2011 (19)
2026 (13)
2010 (11)
2008 (10)
2009 (8)
2007 (4)
2006 (3)
2005 (2)
2004 (2)
2001 (2)
2003 (1)
2002 (1)
1997 (1)

Lab affiliation

Functional Proteomics Lab, Dpt. Life Sciences, University of Siena, Italy (2)
Center for Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China (1)
Centre for Medical Genetics, Institute of Reproductive Genetics, University of Münster, Vesaliusweg 12-14, 48149 Münster, Germany. (1)
Centre for Medical Genetics, Institute of Reproductive Genetics, University of Münster, Vesaliusweg 12-14, 48149, Münster, Germany. (1)
Gene Center of the LMU Munich, LAFUGA Proteomics department, AG Fröhlich Group (1)
Institute for Veterinary Anatomy, Justus Liebig University Giessen Frankfurter Strasse 98, 35392 Giessen, Germany (1)
Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany; Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany; Cardio-Pulmonary Institute, Frankfurt am Main, Germany (1)
Laboratory for RNA Cancer Biology Department of Oncology, LKI, KU Leuven (1)
Research Centre for Genetic Engineering and Biotechnology “Georgi D Efremov”, Macedonian Academy of Sciences and Arts, Skopje, Krste Misirkov 2, 1000 Skopje, Republic of North Macedonia (1)
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China. (1)
State Key Laboratory of Reproductive Medicine. Department of Histology and Embryology, Nanjing Medical University, Nanjing, China (1)
The State Key Laboratory for Complex, Severe, and Rare Diseases; SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China. (1)

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Untargeted metabolomic profiling of seminal plasma in nonobstructive azoospermia men: A noninvasive detection of spermatogenesis

Male factor infertility is involved in almost half of all infertile couples. Lack of the ejaculated sperm owing to testicular malfunction has been reported in 6-10% of infertile men, a condition named nonobstructive azoospermia (NOA). In this study, we investigated untargeted metabolomic profiling o...

2018-04-19 | MTBLS420 | MetaboLights

Transcription profiling of testis biopsies to investigate testis developmental gene expression in cryptorchid boys at risk of azoospermia

Despite timely and successful surgery, 32% of patients with bilateral and 10% with unilateral cryptorchidism will develop azoospermia. Cryptorchid boys at risk of azoospermia display a typical testicular histology of impaired mini-puberty at the time of the orchidopexy. During mini-puberty increased...

ORGANISM(S): Homo sapiens

2010-11-23 | E-GEOD-25518 | biostudies-arrayexpress

Whole Exome Sequencing of two non-obstructive azoospermia patients

We collected blood samples of two non-obstructive azoospermia patients, and performed whole exome sequencing to explore the causal mutations for male infertility.

ORGANISM(S): Homo sapiens

2021-06-22 | E-MTAB-9287 | biostudies-arrayexpress

Potential biomarkers tah could help to determine the prognosis of azoospermia treatment

We analyzed gene expression profiles of human testicular biopsies in men with idiopathic nonobstructive azoospermia who underwent therapy with hCG/rFSH. Using new generation oligonucleotide microarray platform GeneChipÂ® Human Gene 1.0 ST, we identified genes which could be potential prognostic bio...

ORGANISM(S): Homo sapiens

2015-12-31 | E-GEOD-51111 | biostudies-arrayexpress

TMT-based proteomics and phosphoproteomics analysis of proteome changes in seminal plasma extracellular vesicles of azoospermia

The proteome and phosphoproteomics changes were quantified in seminal plasma extracellular vesicles among healthy individuals with normal sperm, nonobstructive azoospermia and obstructive azoospermia using TMT 10-plex by LC-MS/MS.

ORGANISM(S): Homo sapiens (Human)

2021-09-09 | PXD022843 | Pride

Potential biomarkers of non-obstructive azoospermia identified in microarray gene expression analysis

We analyzed gene expression profiles of human testicular biopsies in men with idiopathic nonobstructive azoospermia. Using new generation oligonucleotide microarray platform GeneChipM-BM-. Human Gene 1.0 ST, we identified genes which could be potential biomarkers of azoospermia and molecular indica...

ORGANISM(S): Homo sapiens

2013-09-16 | E-GEOD-45885 | biostudies-arrayexpress

Comparative proteomics analysis of FFPE testicular tissue from men with obstructive and non-obstructive azoospermia

The project aimed to compare testicular proteomes from patients with obstructive and non-obstructive azoospermia in order to identify molecular signatures involved in spermatogenesis as well to identify candidate biomarkers for discriminating between different types of azoospermia. The samples used ...

ORGANISM(S): Homo sapiens (Human)

2022-07-31 | PXD032722 | Pride

Human Testis Ffpe Azoospermia Rapigest Lc-ms/ms

Systematic characterization of seminal plasma piRNAs as molecular biomarkers for male infertility

Although piwi-interacting RNAs (piRNAs) play pivotal roles in spermatogenesis, little is known about piRNAs in the seminal plasma of infertile males. In this study, we systematically investigated the profiles of seminal plasma piRNAs in infertile males to identify piRNAs that are altered during infe...

ORGANISM(S): Homo sapiens

2016-06-28 | E-GEOD-78131 | biostudies-arrayexpress

Transcription profiling of human NOA patients identifies testicular gene expression profile for NOA patients, and ART3 as a genetic susceptibility gene for NOA

Infertility affects about one in six couples attempting pregnancy, with the man responsible in approximately half of the cases. Because the pathophysiology underlying azoospermia is not elucidated, most male infertility is diagnosed as idiopathic. Genome-wide gene expression analyses with microarra...

ORGANISM(S): Homo sapiens

2008-06-16 | E-GEOD-9210 | biostudies-arrayexpress

Mutations in SPINK2 induce azoospermia

Azoospermia, characterized by the absence of spermatozoa in the ejaculate is a common cause of male infertility with a poorly characterized etiology. Exome sequencing analysis of two azoospermic brothers allowed the identification of a homozygous splice mutation in SPINK2, encoding a serine protease...

EGAS00001002450 | EGA

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