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TranscriptomicsTranscription profiling of human dendritic cells matured by cadherin reveals disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation
The maturation of dendritic cells (DCs) after exposure to microbial products or inflammatory mediators plays a critical role in initiating the immune response. We found that maturation can also occur under steady state conditions, triggered by alterations in E-cadherin-mediated DC-DC adhesion. Sele...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9241 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse wild type and E-cadherin knockout embryonic stem cells grown with or without cytokine leukemia inhibitory factor
We previously observed that E-cadherin knockout embryonic stem cells do not differentiate in the absence of the cytokine leukemia inhibitory factor (LIF) (Soncin et al., 2009, Stem Cells 27 p2069-2080). This experiment was designed to compare the transcription profile of E-cadherin KO ES cells cultu...
ORGANISM(S): Mus musculus 
2011-06-19 | E-MEXP-2836 | biostudies-arrayexpress
TranscriptomicsTranscription profile of adipose derived mesenchymal stem cells separated by cell surface protein N-cadherin.
Mesenchymal stem cells (MSCs) are one of most promising stem cell sources for regenerative medicine. MSCs have a differention ability into several tissues. However, their differentiation efficiency is considered quite limited. Especially, the differentiation efficiency into cardiomyocytes is very lo...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-GEOD-35232 | biostudies-arrayexpress
TranscriptomicsParedes_IPATIMUP_Comparison of cell lines derived from BT-20 cells using siRNA to silence E-cadherin and P-cadherin
Gene expression of four cell lines derived from BT-20 cells, namely, BT20 siCtr (E+/P+), BT20 siPcad (E+/P-), BT20 siEcad (E-/P+), and BT20 siEPcad (E-/P-) was compared using Agilent Human GE 4x44k v2 Microarrays and the Agilent One-Color Microarray-Based Gene Expression Analysis protocol (Quick Amp...
ORGANISM(S): Homo sapiens 
2011-10-01 | E-MEXP-3329 | biostudies-arrayexpress
OtherThe N-cadherin interactome in primary cardiomyocytes
Low levels of Cdh2-BioID2 were expressed in mouse primary neonatal cardiomyocytes using an adenoviral expression system. Infected cells were treated with biotin for 24 hours before lysis. Biotinylated proteins were precipitated from lysates using streptavidin beads. Protein samples were in-gel tryps...
ORGANISM(S): Mus Musculus 
2019-01-23 | MSV000083356 | MassIVE
TranscriptomicsTranscription profiling of mouse hematopoetic progenitor cells with Flk12+ Ncad-, Flk12- Ncad+, Flk12+ Ncad+ or Flk12- Ncad- phenotypes
N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells
ORGANISM(S): Mus musculus 
2008-01-04 | E-TABM-404 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse VE-cadherin null cell line vs contrik
In order to identify genes regulated by VE-cadherin expression, we compared a mouse VE-cadherin null cell line (VEC null) with the same line reconstituted with VE-cadherin wild type cDNA (VEC positive). The morphological and functional properties of these cell lines were described previously [Lampug...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-11674 | biostudies-arrayexpress
TranscriptomicsEsophageal keratinocyte invasion after loss of E-cadherin and TGF receptor type II
Esophageal cancer is one of the deadliest cancers as patients present at late stages of disease. Frequent gene alterations include the loss of E-cadherin and TGFb receptor type II. The goal of this study was to establish a model of esophageal cancer by introducing dominant-negative mutants of E-cadh...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-19472 | biostudies-arrayexpress
ProteomicsE-cadherin interactome complexity and robustness resolved by quantitative proteomics
E-cadherin-mediated cell-cell adhesion and signaling plays an essential role in development and maintenance of healthy epithelial tissues. Adhesiveness mediated by E-cadherin is conferred by its extracellular cadherin domains and is regulated by an assembly of adaptors and enzymes associated with it...
ORGANISM(S): Homo sapiens (Human) 
2016-07-06 | PXD000448 | Pride
E-cadherin  silac  label-free  interactome  cancer 
ProteomicsThe N-cadherin interactome in primary cardiomyocytes as defined by quantitative proximity proteomics
Low levels of Cdh2-BioID2 were expressed in mouse primary neonatal cardiomyocytes using an adenoviral expression system. Infected cells were treated with biotin for 24 hours before lysis. Biotinylated proteins were precipitated from lysates using streptavidin beads. Protein samples were in-gel tryps...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-01-24 | MSV000083362 | MassIVE
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