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MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
MetabolomicsProfiling the metabolome of uterine fluid for early detection of ovarian cancer

Ovarian cancer (OC) causes high mortality in women because of ineffective biomarkers for early diagnosis. Here, we perform metabolomics analysis on an initial training set of uterine fluid from 96 gynecological patients. A seven-metabolite-marker panel consisting of vanillylmandelic acid, norepin...

2023-03-06 | MTBLS4861 | MetaboLights
GenomicsHigh-throughput quantification of cell-surface proteins for accelerated cancer therapeutic discovery
High-throughput quantification of cell-surface proteins for accelerated cancer therapeutic discovery
PRJNA1114101 | ENA
ProteomicsSurfactant-assisted one-pot sample preparation for label-free single-cell proteomics
Large numbers of cells are generally required for quantitative global proteome profiling due to the significant surface adsorption losses associated with sample processing. Such bulk measurement obscures important cell-to-cell variability (cell heterogeneity) and makes proteomic profiling impossible...
ORGANISM(S): Homo Sapiens 
2021-03-11 | PXD022827 | panorama
ProteomicsRB383 retinoblastoma cell line surface proteome
The proteins on the surface of RB383 retinoblastoma cell line were analyzed by cell surface biotinylation and streptavidin affinity purification.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039518 | Pride
Retinoblastoma Cell surface proteome 
ProteomicsY79 retinoblastoma cell line surface proteome
The proteins on the surface of Y79 retinoblastoma cell line were analyzed by cell surface biotinylation and streptavidin affinity purification.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039517 | Pride
Retinoblastoma Cell surface proteome 
ProteomicsIntegrative proteomic profiling of ovarian cancer cell lines reveals precursor-cell associated proteins and functional status
A cell line representative of human high-grade serous ovarian cancer (HGSOC) should not only resemble its tumor of origin at the molecular level, but also demonstrate functional utility in pre-clinical investigations. Here we report the integrated proteomic analysis of 26 ovarian cancer cell lines, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-30 | MSV000080814 | MassIVE
ProteomicsProteomic analysis of human SKBR3/HER2+ breast cancer cell-surface proteins by using tryptic shaving
The plasma membrane proteome resides at the interface between the extra- and intra-cellular environment and through its various roles in signal transduction, immune recognition, nutrient transport, and cell-cell and cell-matrix interactions plays a critical role in determining the fate of a cell. Th...
ORGANISM(S): Homo sapiens (Human) 
2022-07-11 | PXD028978 | Pride
Cancer Skbr3 cells Cell-surface proteins 
ProteomicsSurface proteome profiling of p53-restorable murine liver cancer cells
Characterization of the surface proteome changes between proliferating and senescent liver cancer cells induced by p53 restoration.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD034465 | Pride
Surface proteome P53 restoration Liver cancer Senescence 
ProteomicsProteomic analysis of human SKBR3/HER2+ breast cancer cell-surface proteins by using amine group biotinylation
The plasma membrane proteome resides at the interface between the extra- and intra-cellular environment and through its various roles in signal transduction, immune recognition, nutrient transport, and cell-cell and cell-matrix interactions plays a critical role in determining the fate of a cell. Th...
ORGANISM(S): Homo sapiens (Human) 
2022-07-11 | PXD028977 | Pride
Cancer Skbr3 cells Cell-surface proteins 
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