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MetabolomicsSeipin Governs Caveolin-1 Trafficking Through Modulating Sphingolipid-Glycerolipid Balance

Dysregulation of Caveolin-1 (CAV1), a key component of caveolae, leads to pleiotropic disorders; yet, the mechanisms controlling its trafficking remain unclear. Here, we show that the lipid droplet (LD) biogenesis factor seipin controls CAV1 localization. Seipin deficiency in mice and HeLa cells ...

2025-07-22 | MTBLS12759 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1977 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1969 | MetaboLights
TranscriptomicsTranscription profiling by array of human HT29 colon cancer cells to investigate the role of Caveolin 1, E-Cadherin, Enolase 2 and PKCa on resistance to methotrexate
A summary of the work associated to these microarrays is the following:; Methotrexate (MTX) is one of the earliest cytotoxic drugs used in cancer therapy, and despite the isolation of multiple other folate antagonists, methotrexate maintains its significant role as a treatment for different types of...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11440 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse WT and Cav-3 knockouts on FVB/N genetic background mammary glands reveals loss of caveolin-3 induces the development of a lactogenic microenvironment
Here, we show that functional loss of a single gene is sufficient to confer constitutive milk protein production and protection against mammary tumor formation. Caveolin-3 (Cav-3), a muscle-specific caveolin-related gene, is highly expressed in striated and smooth muscle cells. We demonstrate that C...
ORGANISM(S): Mus musculus 
2009-01-31 | E-GEOD-12881 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse caveolin-3 knockout hearts
Energy Substrate Uptake and Metabolism are Preserved in Hypertrophic Caveolin-3 Knockout Hearts Experiment Overall Design: 3 wild types, 3 knockouts
ORGANISM(S): Mus musculus 
2009-03-15 | E-GEOD-10848 | biostudies-arrayexpress
TranscriptomicsLunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-Like Breast Cancer
SUMMARY: Basal breast cancer has been associated with mutations in a number of specific tumor suppressor genes, however, the mechanism by which these tumors express a basal lineage remains unknown. Notch signaling suppresses mammary stem cell (MaSC) self-renewal, while promoting luminal cell fate s...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-28712 | biostudies-arrayexpress
TranscriptomicsTranscription profiliing of mouse caveolin-1 knockout hearts
Hearts Lacking Caveolin-1 Develop Hypertrophy with Normal Cardiac Substrate Metabolism Experiment Overall Design: 3 wild types, 3 knockouts
ORGANISM(S): Mus musculus 
2009-03-15 | E-GEOD-10849 | biostudies-arrayexpress
ProteomicsThe ambiguous Caveolin-3 G55S sequence variant: Muscle biopsy findings and cell biological analysis
Caveolins are structural and functional proteins in plasma membrane invaginations called caveolae. Mutations in Caveolin-3 cause myopathies of variable severity. The pathogenicity of the Caveolin-3 variant G55S is still unclear. Here, we report on three patients suffering from mild to moderate myopa...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD003719 | Pride
Lgmd1d Rcmh Caveolin-3 Proteome profile of muscle cells 
TranscriptomicsLS001A: Aging/Early Degeneration Of The Intervertebral Disc Involves Downregulation Of Canonical Wnt Signaling and Caveolin-1 expression
Objective: Aging and early degeneration of the intervertebral disc (IVD) involves the substition of notochordal cells (NCs) in the nucleus pulposus (NP) by chondrocyte-like cells (CLCs). This study investigated the gene expression profiles involved in this process using NP tissue from both non-chond...
ORGANISM(S): Canis lupus familiaris 
2013-01-31 | E-GEOD-35717 | biostudies-arrayexpress
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