INTRODUCTION: Premature adrenarche (PA) for long time was considered a benign condition but later has been connected to various diseases in childhood and adulthood which remains controversial.

OBJECTIVE: To investigate the effect of premature adrenarche ...

Traditional Chinese Medicine Dachaihu decoction (DCHD) has been reported to hold great promise to alleviate autism spectrum disorders (ASD), a generalized neurodevelopmental disease associated with gut microbiome dysbiosis. Health-promoting effects of DCHD on ASD children could be attributed to g...

Three groups of eligible subjects were included, including 20 cases in the HSP group, 20 cases in the HSPN group, and 20 cases in the healthy control (HC) group. Nasal lavage samples from each group were subjected to 16SrRNA gene sequencing and metabolomic analyses to screen differential flora an...

OBJECTIVE: Childhood obesity is a strong risk factor for adult obesity and metabolic diseases, including type 2 diabetes and cardiovascular disease. Early lifestyle intervention in children with obesity reduces future disease risk. The objective of this study is to identify metab...

Children born to women with HIV (WWH) suffer increased morbidity and, in low-income settings, have two to three times the mortality of infants born to women without HIV. The basis for this increase remains elusive. In low-income settings, breastfeeding is recommended because health benefits outwe...

Cariogenic microorganisms as well as salivary metabolic status in early childhood caries (ECC) have been reported to differ from that in adult caries. The main aim of this study was to identify specific microbial species and salivary metabolites in children with ECC using species-specific qPCR an...

Children born to women with HIV (WWH) suffer increased morbidity and, in low-income settings, have two to three times the mortality of infants born to women without HIV. The basis for this increase remains elusive. In low-income settings, breastfeeding is recommended because health benefits outwe...

Sepsis, defined as life-threatening organ dysfunction caused by infection is difficult to distinguish clinically from infection or post-operative inflammation. We hypothesized that in a heterogeneous group of critically ill children, there would be different metabolic profiles between post-operat...

To determine the gut microbiota and urine metabolomics signature and identify the regional characteristics in Autism spectrum disorder (ASD), we conducted a cohort study of 88 well-characterized participants from Guangxi Zhuang Autonomous Region in Southern China. Gut microbiota and urine metabo...