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MetabolomicsComprehensive evaluation of untargeted metabolomics data processing software in feature detection, quantification and discriminating marker selection
Data analysis represents a key challenge for untargeted metabolomics studies and it commonly requires extensive processing of more than thousands of metabolite peaks included in raw high-resolution MS data. Although a number of software packages have been developed to facilitate untargeted data proc...
2019-11-19 | MTBLS733 | MetaboLights
MetabolomicsComprehensive evaluation of untargeted metabolomics data processing software in feature detection, quantification and discriminating marker selection (AB SCIEX TripleTOF 6600 assay)

Data analysis represents a key challenge for untargeted metabolomics studies and it commonly requires extensive processing of more than thousands of metabolite peaks included in raw high-resolution MS data. Although a number of software packages have been developed to facilitate untargeted data p...

2019-11-19 | MTBLS736 | MetaboLights
MetabolomicsComparative analysis of the adaptation of Staphylococcus aureus to internalization by different types of human non-professional phagocytic host cells (NMR assay)
Staphylococcus aureus is a human pathogen that can cause a wide range of diseases. Although formerly regarded as extracellular pathogen, it has been shown that S. aureus can also be internalized by host cells and persist within these cells. In the present study, we comparatively analyzed survival an...
2015-07-01 | MTBLS102 | MetaboLights
MetabolomicsComparative metabolomics reveals serum metabolites changes in goats during different developmental stages

Goats can provide meat, milk and skins for humans and are livestock with high economic benefits. However, despite their economic significance, the comprehensive analysis of goats' serum metabolic profile and its intricate alterations throughout their developmental journey remains conspicuously ab...

2024-06-04 | MTBLS8944 | MetaboLights
ProteomicsSpecific mixing facilitates the comparative quantification of phosphorylation sites with significant dysregulations
It is still a big challenge to accurately quantify the proteins or proteins PTM sites with extreme relative abundances in comparative protein samples, such as the significantly dysregulated ones. Herein, a novel quantification strategy, Mixing at Specific Ratio (MaSR) before isotope labeling, had be...
ORGANISM(S): Candida albicans (Yeast) Homo sapiens (Human) Escherichia coli 
2016-12-06 | PXD005181 | Pride
Lc-msms Mixing at specific ratio Comparative phosphoproteome quantification Stable isotope labeling Extreme relative abundance 
MetabolomicsUnveiling superior phenol detoxification and degradation ability in Candida tropicalis SHC-03: A comparative study with Saccharomyces cerevisiae BY4742

This study examined the phenol degradation capabilities and oxidative stress responses of Candida tropicalis SHC-03, demonstrating its metabolic superiority and resilience compared to Saccharomyces cerevisiae BY4742 in a culture medium with phenol as the sole carbon source. Through comparative gr...

2024-10-04 | MTBLS10757 | MetaboLights
MetabolomicsDeciphering metabolomic alterations in seminal plasma of crossbred (Bos taurus X Bos indicus) bulls through comparative deep metabolomic analysis
The incidence of sub-fertility is higher in crossbred bulls compared to zebu bulls. In the present study, we analysed the metabolomic profile of seminal plasma from crossbred and zebu bulls and uncovered differentially expressed metabolites between these two breeds. Using a high-throughput LC-MS/MS-...
2021-12-22 | MTBLS1642 | MetaboLights
MetabolomicsComparative non-targeted metabolomic profiling of PEDV-infected versus uninfected neonatal piglets

Three-day-old piglets were orally inoculated with L. reuteri, with age-matched untreated piglets serving as controls. Five days post-inoculation, all piglets were challenged with PEDV. Jejunal contents were collected during acute infection for non-targeted metabolomic profiling.For non-disea...

2025-07-04 | MTBLS12632 | MetaboLights
MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
ProteomicsComparative Evaluation of MaxQuant and Proteome Discoverer MS1-based Protein Quantification Tools
MS1-based label-free quantification can compare precursor ion peaks across runs, allowing reproducible protein measurements. Among bioinformatic platforms enabling MS1-based quantification, MaxQuant (MQ) is one of the most used, while Proteome Discoverer (PD) has recently introduced the Minora tool....
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2021-05-31 | PXD022169 | Pride
Dynamic range Proteomics Mass spectrometry Specificity Sensitivity Accuracy Precision Label-free quantification Differential analysis 
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