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GenomicsTargeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor (ChIP-Seq)
Cyclin-dependent kinase 7 (CDK7) plays a critical role in the general regulation of RNA polymerase II-mediated transcription. However, the absence of selective CDK7 inhibitors has hindered the ability to investigate the consequences of acute and prolonged inhibition of CDK7 under normal and patholo...
ORGANISM(S): Homo sapiens 
2013-12-23 | E-GEOD-50622 | biostudies-arrayexpress
ProteomicsStructural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Inhibition of the mitochondrial deubiquitinating enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson’s Disease and mitophagy-related disorders. We have integrated structural and quantitative proteomics with biochemical assays to decipher t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054057 | Pride
Ubiquitin specific protease usp30  cyanopyrrolidine inhibitors Activity-based protein profiling mass spectrometry  enzyme kinetics  hydrogen deuterium exchange-mass spectrometry  molecular docking Mitophagy 
ProteomicsIntact mass spectrometry analysis of covalent binding between purified recombinant human FGFR2 V564F protein and small-molecule compound LC-F2-1 incubated at a molar ratio of 1:2 or 1:5 at room temperature via Agilent 6230 time-of-flight LC/MS system for the characterization of their covalent binding products in protein-drug interaction studies
This dataset corresponds to an intact mass spectrometry study focusing on the covalent binding interaction between purified FGFR2 V564F protein and compound LC-F2-1. The purified FGFR2 V564F was adjusted to 28 μM, then incubated with LC-F2-1 at molar ratios of 1:2 or 1:5 for 4 hours at room temperat...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD073416 | Pride
Covalent binding Lc-ms Lc-f2-1 Fgfr2 v564f 
ProteomicsStructural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Inhibition of the mitochondrial deubiquitinating enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson’s Disease and mitophagy-related disorders. We have integrated structural and quantitative proteomics with biochemical assays to decipher t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054041 | Pride
Ubiquitin specific protease usp30  cyanopyrrolidine inhibitors Activity-based protein profiling mass spectrometry  enzyme kinetics  hydrogen deuterium exchange-mass spectrometry  molecular docking Mitophagy 
GenomicsCovalent inhibitor of the Rho family inhibits the migration of breast cancer cells
Covalent inhibitor of the Rho family inhibits the migration of breast cancer cells
PRJNA417393 | ENA
ProteomicsIntegrative analysis of Multi-omics data of FGFR inhibitor
Dissection of the mechanism of action of FGFR inhibitor by multi-omic analysis
ORGANISM(S): Homo Sapiens 
2025-02-05 | PXD060496 |
GenomicsSulfopin, a covalent inhibitor of Pin1, blocks Myc-driven tumors in vivo
Sulfopin, a covalent inhibitor of Pin1, blocks Myc-driven tumors in vivo
PRJNA701956 | ENA
GenomicsDevelopment of a selective CDK7 covalent inhibitor reveals predominant cell cycle phenotype
Development of a selective CDK7 covalent inhibitor reveals predominant cell cycle phenotype
PRJNA512643 | ENA
GenomicsTargeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-12-23 | E-GEOD-50625 | biostudies-arrayexpress
GenomicsIdentification of covalent small-molecule inhibitors of STING
Identification of covalent small-molecule inhibitors of STING
PRJNA454500 | ENA
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