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GenomicsLigand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer
Glucocorticoids (GC) have been widely used as coadjuvants in the treatment of solid tumors, but GC treatment may be associated with poor pharmacotherapeutic response and/or prognosis. The genomic action of GC in these tumors is largely unknown. Here we find that dexamethasone (Dex, a synthetic GC) r...
ORGANISM(S): Homo sapiens 
2015-09-18 | E-GEOD-56022 | biostudies-arrayexpress
ProteomicsThe autophagy receptor p62/SQSTM1 mediates anti-inflammatory actions of the selective glucocorticoid receptor modulator CpdA in macrophages
Glucocorticoids are widely used to treat inflammatory disorders. Prolonged use results in side effects including osteoporosis, diabetes and obesity. The selective glucocorticoid receptor (GR) modulator Compound A (CpdA) exhibits an inflammation-suppressive effect, largely in absence of detrimental s...
ORGANISM(S): Homo sapiens (Human) 
2022-06-03 | PXD007793 | Pride
Autophagy P62/sqstm1 Inflammation Nrf2-signaling Cpda Glucocorticoids Autophagy receptors Lc-ms/ms 
ProteomicsThe auophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages
Glucocorticoids are widely used to treat inflammatory disorders; however, prolonged use of glucocorticoids results in side effects including osteoporosis, diabetes and obesity. Compound A (CpdA), identified as a selective NR3C1/glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-11 | PXD012121 | Pride
Autophagy  autophagy receptors  cpda  glucocorticoids  inflammation  nfe2l2/nrf2  sqstm1/p62 
TranscriptomicsRNA sequencing of ATCC 17978hm Acineotbacter baumannii strain and CpdA mutant
Difference in RNA expression levels between Acinetobacter baumannii cells expressing high and low levels of cyclic AMP Total RNA obtained from Acineotbacter baumannii bacterial cells in Log phase gown in MH broth culture, isolated RNA in triplicate from three expreiment. cpdA::Tn mutant and 17978hm ...
ORGANISM(S): Acinetobacter baumannii 
2015-06-21 | E-GEOD-64935 | biostudies-arrayexpress
UnknownExpression of the cpdA gene, encoding a 3',5'-cyclic AMP (cAMP) phosphodiesterase, is positively regulated by the cAMP-cAMP receptor protein complex.
Not available
S-EPMC2632089 | biostudies-literature
TranscriptomicscAMP phosphodiesterase CpdA of Corynebacterium glutamicum: identification, characterization, influence on cAMP level, growth, and global expression, and transcriptional activation by GlxR
DNA microarrays were applied to investigate the effect of cpdA deletion (del) or overexpression (over) on the global gene expression of C. glutamicum cells. For overexpression of cpdA the gene was cloned into plasmid pEKEx2 under control of the IPTG-inducible tac promoter, which was induced by addit...
ORGANISM(S): Corynebacterium glutamicum Gluconobacter oxydans Escherichia coli Bacillus subtilis subsp. subtilis str. 168 
2016-11-15 | GSE81004 | GEO
UnknownIn vitro and in vivo characterization of the Pseudomonas aeruginosa cyclic AMP (cAMP) phosphodiesterase CpdA, required for cAMP homeostasis and virulence factor regulation.
Not available
S-EPMC2876501 | biostudies-literature
TranscriptomicsComparative analysis of gene expression profiles in lymphoma cells after treatment by Dexamethasone or CpdA
The project is directed to the development of selective glucocorticoid receptor agonists for anticancer therapy. Glucocorticoids (GC) are widely used in treatment of many types of cancer due to its ability to induce apoptosis in malignant cells (in blood cancer therapy) and to prevent nausea and eme...
ORGANISM(S): Homo sapiens 
2015-07-21 | GSE71102 | GEO
TranscriptomicsComparative analysis of gene expression profiles in prostate cancer cells after treatment by Dexamethasone or CpdA
The project is directed to the development of selective glucocorticoid receptor agonists for anticancer therapy. Glucocorticoids (GC) are widely used in treatment of many types of cancer due to its ability to induce apoptosis in malignant cells (in blood cancer therapy) and to prevent nausea and eme...
ORGANISM(S): Homo sapiens 
2015-07-21 | GSE71099 | GEO
UnknownIn vitro quality and hemostatic function of cold-stored CPDA-1 whole blood after repeated transient exposure to 28°C storage temperature.
Not available
S-EPMC9541954 | biostudies-literature
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