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ProteomicsXL-MS and Native MS for CSN-CRL2 complexes
Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through specific substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by removing NEDD8 (N8) from activated Cullins. The structure of stable CSN-CRL can be used to understand this mechanism of regulation. Here we pre...
ORGANISM(S): Homo sapiens (Human) 
2019-09-13 | PXD013018 | Pride
Xl-ms Mass spectrometry Crl2 Cop9 signalosome Native ms Cullin ring e3 ligase 
ProteomicsTitle Heme acts as a molecular degrader linking CRL2-FEM1B to substrate proteolysis and ferroptosis regulation in lung cancer
In this project, we attempted to explore the differential proteins profile of lung cancer cells in which the BACH1-CRL2 pathway was manipulated. To this end, we performed DIA-based quantitative proteomics in mouse lung adenocarcinoma KP cells. Control cells and BACH1 null cells were used. Additiona...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-11 | PXD062953 | Pride
Kp  bach1  crl2  nsclc  lc-msms  dia 
TranscriptomicsCRL2-FEM1B uses heme to recruit BACH1 for degradation and regulate ferroptosis in lung cancer
The goal of this study is to characterize the transcriptional programs regulated by the BACH1–CRL2-FEM1B axis in mouse lung adenocarcinoma cells.
ORGANISM(S): Mus musculus 
2026-06-11 | GSE294756 | GEO
GenomicsCRL2-FEM1B uses heme to recruit BACH1 for degradation and regulate ferroptosis in lung cancer
CRL2-FEM1B uses heme to recruit BACH1 for degradation and regulate ferroptosis in lung cancer
PRJNA1251558 | ENA
UnknownSELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.
Not available
S-EPMC4766860 | biostudies-literature
UnknownCRL2(LRR-1) E3-ligase regulates proliferation and progression through meiosis in the Caenorhabditis elegans germline.
Not available
S-EPMC3610609 | biostudies-literature
Unknown<i>Mycobacterium tuberculosis</i> effector protein PE5 hijacks the host CRL2 ubiquitin ligase complex.
Not available
S-EPMC12259106 | biostudies-literature
UnknownCRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells.
Not available
S-EPMC3053091 | biostudies-literature
UnknownQuantitative analyses for effects of neddylation on CRL2VHL substrate ubiquitination and degradation.
Not available
S-EPMC8521307 | biostudies-literature
ProteomicsSILAC proteomics studying the role of CAND1 in CRL2 dynamics
Effects of CAND1 and neddylation/deneddylation on CRL2 dynamics.
ORGANISM(S): Homo sapiens (Human) 
2023-12-18 | PXD045609 | Pride
Cul2 exchange 
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