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MetabolomicsCurcumin (analogue) metabolites in intestinal cell lines
Curcumin and curcumin-based benzothiazepane analogues were investigated in intestinal cell lines of cancer (HCT-116) and non-cancer (IPEC-J2) origin. After 0h, 3h and 15h incubation, the cell lysates and extracellular media were analysed using LC-QTOF-MS.
2026-07-20 | MTBLS15099 | MetaboLights
MetabolomicsExploring the Effects and Mechanisms of Curcumin on Proliferation, Apoptosis, and Oxidative Stress in Hepatoblastoma cell line via the TLR4/TRAF6/MAPKs Pathway

A combination of bioinformatics and network pharmacology was used to screen curcumin's target genes and related signaling pathways in treating hepatocellular carcinoma. Curcumin-Containing Serum（CUR） was prepared. Cisplatin(CDDP) served as the positive control .The CCK-8 assay, scratch assay, and...

2025-11-28 | MTBLS13412 | MetaboLights
TranscriptomicsCurcumin Extends Lifespan, Improves Healthspan, and Modulates the Expression of Age-Associated Aging Genes in Drosophila melanogaster
Curcumin, a yellow pigment extracted from the rhizome of the plant Curcuma longa (turmeric) has been widely used as a spice and herbal medicine in Asia. It has been suggested to have many biological activities such as anti-oxidative, anti-inflammatory, anti-cancer, chemopreventive, and anti-neurodeg...
ORGANISM(S): Drosophila melanogaster 
2010-04-06 | E-GEOD-21182 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocytes (U937 cell line) to assess the impact of curcumin on monocytes exposed to oxidative stress
Oxidative stress as a result of cigarette smoking is an important etiological factor in the pathogenesis of chronic obstructive pulmonary disease (COPD), a chronic steroid-insensitive inflammatory disease of the airways. The activity of the transcriptional co-repressor Histone deacetylase-2 (HDAC2) ...
ORGANISM(S): Homo sapiens 
2009-12-17 | E-GEOD-10896 | biostudies-arrayexpress
TranscriptomicsEffect of Curcumin on expression profile of Schistosoma mansoni adult worms
Transcriptional profiling of Curcumin treated S. mansoni adult worms (15uM of Curcumin in DMSO during 24h) vs. Non-treated S.mansoni adult worms (DMSO during 24h) Two conditions (treated vs. Non-treated) with four biological samples of treated worms (Curcumin 1, 2, 3 and 4) and four biological sampl...
ORGANISM(S): Schistosoma mansoni 
2012-12-30 | E-GEOD-37647 | biostudies-arrayexpress
TranscriptomicsThe effects of dietary curcumin on colonic gene expression in TNBS-induced colitis
Curcumin is a potent anti-inflammatory compound capable of preventing chemically induced colitis in mice. We used microarray analysis to detail the global programme of colonic gene expression in BALB/c mice fed standard or 2% curcumin-supplemented diet and treated with control or TNBS (trnitrobenzen...
ORGANISM(S): Mus musculus 
2008-11-21 | E-GEOD-13705 | biostudies-arrayexpress
ProteomicsBacillus subtilis under Curcumin treatment LC-MS/MS
Comprehensive Analysis of Temporal Alterations in Cellular Proteome of Bacillus subtilis under Curcumin Treatment
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2019-11-20 | PXD000644 | Pride
Bacillus Curcumin Lc-ms/ms 
TranscriptomicsTranscriptomic definition of curcumin treated microglia
Curcumin is a potent modulator of the inflammatory transcriptome in microglia We have performed global gene expression analysis of BV-2 microglial cells under the following conditions: untreated, 20 µM Curcumin-treated, 100ng/ml LPS-treated, or 20 µM Curcumin-treated + 100ng/ml LPS-treated
ORGANISM(S): Mus musculus 
2010-09-29 | E-GEOD-23639 | biostudies-arrayexpress
ProteomicsSWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1α axis.
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by expression of the chimeric BCR-ABL tyrosine kinase oncogene, resulting from the t(9;22) chromosomal translocation. Imatinib (gleevec, STI-571) is a selective inhibitor of Bcr-Abl activity highly effective in the treatment...
ORGANISM(S): Homo sapiens (Human) 
2018-07-30 | PXD007771 | Pride
Swath-ms  cml cells  curcumin 
ProteomicsPhosphotyrosine profiling of curcumin-induced signaling
Curcumin, derived from the rhizome of Curcuma longa is a natural anti-cancer agent and has been shown to inhibit proliferation and survival of tumor cells. Although the anti-cancer effects of curcumin are well established, detailed understanding of the signaling pathways altered by curcumin is still...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002097 | Pride
Immunoaffinity purification Curcumin Head and neck squamous cell carcinoma 
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