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TranscriptomicsChromatin immunoprecipitation of human cell lines to identify cAMP-response element binding protein (CREB) binding sites.
Hormones and nutrients often induce genetic programs via signaling pathways that interface with gene-specific activators. Activation of the cAMP pathway, for example, stimulates cellular gene expression by means of the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB) at S...
ORGANISM(S): Homo sapiens 
2006-05-09 | E-WMIT-11 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fetal lung from wild type and CREB knock-out mice
The cAMP response element binding protein (Creb) is a member of a leucine zipper transcription factor family that regulates gene expression primarily in response to the intracellular cAMP signalling pathway. Previous studies have shown Creb1-null mice suffer respiratory failure with lung atelectasis...
ORGANISM(S): Mus musculus 
2009-04-30 | E-MEXP-1295 | biostudies-arrayexpress
UnknownHIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein.
Not available
S-EPMC9124804 | biostudies-literature
UnknownCyclic AMP response element-binding protein prevents endothelial permeability increase through transcriptional controlling p190RhoGAP expression.
Not available
S-EPMC3251234 | biostudies-literature
GenomicsDorsal dependent CBP binding on a genome wide scale
We find a high concordance between the binding of the Drosophila transcription factor Dorsal and the co-activator CBP during early embryogenesis. This relationship was furter examined by comparing CBP distribution in Drosophila embryos derived from wt and mutant flies lacking intranuclear Dorsal (gd...
ORGANISM(S): Drosophila melanogaster 
2012-06-28 | E-GEOD-34221 | biostudies-arrayexpress
TranscriptomicsCBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.
The epigenetic changes of the chromatin represent an attractive molecular substrate for adaptation to the environment. We examined here the role of CBP, a histone acetyltransferase involved in mental retardation, in the genesis and maintenance of long-lasting systemic and behavioral adaptations to e...
ORGANISM(S): Mus musculus 
2011-08-29 | E-GEOD-30880 | biostudies-arrayexpress
ProteomicsHIV-1 gp120 impairs spatial memory through CREB
HIV-associated neurocognitive disorders (HAND) remain an unsolved problem that persists despite using antiretroviral therapy. We have obtained data showing that HIV-gp120 protein contributes to neurodegeneration through metabolic reprogramming. This led to decreased ATP levels, lower mitochondrial D...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD031891 | Pride
Rolipram Mitochondria Creb protein Proteomics Hiv Neurodegeneration 
UnknownPI3Kγ (Phosphoinositide 3-Kinase γ) Regulates Vascular Smooth Muscle Cell Phenotypic Modulation and Neointimal Formation Through CREB (Cyclic AMP-Response Element Binding Protein)/YAP (Yes-Associated Protein) Signaling.
Not available
S-EPMC6393180 | biostudies-literature
UnknownSelective Inhibition of β-Catenin/Co-Activator Cyclic AMP Response Element-Binding Protein-Dependent Signaling Prevents the Emergence of Hapten-Induced Atopic Dermatitis-Like Dermatitis.
Not available
S-EPMC7992594 | biostudies-literature
TranscriptomicsTranscription profiling of human LNCaP cell lines transfected with AIbZIP
Androgen-induced bZIP (AIbZIP) is a basic leucine zipper (bZIP); transcription factor that is encoded by the CREB3L4 (cAMP responsive element; binding protein 3-like 4) gene. In humans, AIbZIP mRNA is most abundant in; the prostate but it is also present, albeit at much lower levels, in the; pancrea...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7223 | biostudies-arrayexpress
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