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MetabolomicsMicroglia contributes to bipolar depression through Serinc2-dependent phospholipid synthesis

Although clinical research has revealed microglia-related inflammatory and immune responses in bipolar disorder (BD) patient brains, it remains unclear how microglia contribute to the pathogenesis of BD. Here, we demonstrated that Serinc2 is associated with susceptibility to BD and showed a reduc...

2025-08-27 | MTBLS12830 | MetaboLights
MetabolomicsEffects of Platycodins Folium on Depression in Mice Based on a UPLC-Q/TOF-MS Serum Assay and Hippocampus Metabolomics
Major depressive disorder (MDD), also known as depression, is a state characterized by low mood and aversion to activity. Platycodins Folium (PF) is the dried leaf of Platycodon grandiflorum, with anti-inflammatory and antioxidative activities. Our previous research suggested that PF was rich in fla...
2020-06-03 | MTBLS952 | MetaboLights
MetabolomicsThe nasal microbiome and metabolites are altered in depression patients
Depressive disorder is a heterogeneous neuropsychiatric disorder. It affects millions of people worldwide. The exact causes of depressive behavior remain unclear and are believed to implicate both genetic and environmental factors. In the past decade, there have been numerous studies on the dysbiosi...
2025-07-21 | MTBLS10742 | MetaboLights
MetabolomicsAltered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and IBS-specific microbi...

2021-12-01 | MTBLS2774 | MetaboLights
MetabolomicsBioinspired Nanozyme-Exoskeletonized Yeast-derived Polysaccharides for Treating Comorbid Anxiety and Depression in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic condition frequently accompanied by psychological comorbidities, such as anxiety and depression. Although current treatments may alleviate some of these symptoms, the intricate pathogenesis of these comorbidities highlights an urgent need for the deve...

2026-03-24 | MTBLS14127 | MetaboLights
MetabolomicsMichigan Biomarkers for Refractory Depression (Bluebird) metabolomics pilot study
Not available
ORGANISM(S): Homo sapiens 
ST000775 | MetabolomicsWorkbench
TranscriptomicsExpression Profiling of a Genetic Animal Model of Depression
Expression Profiling of a Genetic Animal Model of Depression Reveals Novel Molecular Pathways Underlying Depressive-like Behaviours In this study we have used genome-wide microarray expression profiling of the hippocampus and prefrontal/frontal cortex of Flinders Depression Sensitive (FSL) and cont...
ORGANISM(S): Rattus norvegicus 
2010-04-01 | E-GEOD-20388 | biostudies-arrayexpress
TranscriptomicsMolecular signatures of peripheral blood mononuclear cells following chronic IFN-alpha: Relationship of OAS2 with Depression and Fatigue
Interferon (IFN)-alpha causes high rates of depression and fatigue, and is used to investigate the impact of innate immune cytokines on brain and behavior. However, little is known about transcriptional profiles of circulating immune cells during chronic IFN-alpha administration. Accordingly, genome...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-31187 | biostudies-arrayexpress
MetabolomicsBiomarkers for Depression in Human Plasma in a Population Sample
Not available
ORGANISM(S): Homo sapiens 
ST000062 | MetabolomicsWorkbench
MetabolomicsBiomarkers for Depression in Human Cerebrospinal Fluid in a Population Sample
Not available
ORGANISM(S): Homo sapiens 
ST000063 | MetabolomicsWorkbench
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