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ProteomicsFlap endonuclease 1 repairs DNA-protein crosslinks via ADP-ribosylation
The protein composition of DNA-protein crosslinks (DPCs) induced by formaldehyde treatment of human cell lines was analyzed by mass spectrometry.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-14 | MSV000095039 | MassIVE
ProteomicsIdentification of formaldehyde-induced DNA-protein crosslinks by PxP-MS
Compromised enzymatic actions, reactive metabolites, and various chemotherapeutics cause toxic covalent DNA-protein crosslinks (DPCs). Failure to repair DPCs results in genomic instability, premature aging, and tumorigenesis. However, understanding the principles underlying DPC formation and repair ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-20 | PXD026654 | Pride
Formaldehyde Pxp Dna-protein crosslinks Sprtn 
ProteomicsMetalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Removal
Cytotoxicity of DNA-protein crosslinks (DPCs) is ascribed largely to their ability to block the progression of DNA replication fork. DPCs are frequently occurring in cells, either as a consequence of metabolism or exogenous agents. The mechanism of DPCs removal is not completely understood. Here, we...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080743 | MassIVE
ProteomicsA SUMO-mediated protective response to DNA-protein crosslinks
DNA-protein crosslinks (DPCs) are highly cytotoxic lesions that obstruct essential DNA transactions and whose resolution is critical for cell and organismal fitness. However, unlike the repair pathways for most types of DNA damage, the mechanisms by which cells respond to and overcome DPCs remain po...
ORGANISM(S): Homo sapiens (Human) 
2019-03-26 | PXD009040 | Pride
Q exactive hf-x Sumo Dna repair Q exactive hf Human Dna-protein crosslink Dna damage Dnmt1 Ubquitin 
ProteomicsCSB promotes transcription-coupled repair of DNA-protein crosslinks
PxP-MS (Purification of x-linked Proteins coupled to Mass Spectrometry) was used to assess the role of CSB in DNA-protein crosslink repair. The CSB protein is a sensor that can detect stalled RNA polymerases at sites of DNA damage, thereby triggering transcription-coupled repair mechanisms. DPCs wer...
ORGANISM(S): Homo sapiens (Human) 
2024-02-15 | PXD047668 | Pride
Cockayne syndrome Formaldehyde Dna damage repair Dna-protein crosslinks Csb 
UnknownDNA-protein crosslinks are repaired via homologous recombination in mammalian mitochondria.
Not available
S-EPMC7855827 | biostudies-literature
GenomicsReversible 5-formyluracil DNA-histone crosslinks: formation and biological effects
Reversible 5-formyluracil DNA-histone crosslinks: formation and biological effects
PRJNA551149 | ENA
ProteomicsPrimPol primase mediates replication traverse of DNA interstrand crosslinks
Human cancer cells rely on PRIMPOL primase activity to mediate ICL traverse, sustain DNA synthesis and complete DNA replication
ORGANISM(S): Homo sapiens (Human) 
2021-05-20 | PXD017951 | Pride
Human Unwinding of dna Primase-polymerase Interstrand crosslinks 
ProteomicsMapping protein-DNA interactions by UV femtosecond laser crosslinking and mass spectrometry analysis
Transcription factors (TFs) regulate target genes by specific interaction with DNA sequences. Detecting and understanding these interactions on molecular level is of fundamental interest in both biological and clinical context. Crosslinking mass spectrometry is a powerful tool to assist structure pr...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Sus scrofa domesticus (domestic pig) 
2020-06-22 | PXD014898 | Pride
Femtosecond laser Uv Transcription factor Protein-dna crosslinking Mass spectrometry 
ProteomicsProteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links part 2 of 2: AP-MS DATA (QUBIC)
DNA interstrand crosslinks (ICLs) block replication fork progression by inhibiting DNA strand separation. Repair of ICLs requires sequential incisions, translesion DNA synthesis, and homologous recombination, but the full set of factors involved in these transactions remains unknown. Here we establi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-13 | MSV000079577 | MassIVE
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