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ProteomicsChIP-MS of DPPA3/STELLA in mouse embryonic stem cells
Genome-wide DNA demethylation is a unique feature of mammalian development and naïve pluripotent stem cells. So far, it was unclear how mammals specifically achieve global DNA hypomethylation, given the high conservation of the DNA (de-)methylation machinery among vertebrates. We found that DNA deme...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-12 | PXD019794 | Pride
Epigenetics Dna methylation Escs Chip-ms 
GenomicsLINE-1 DNA methylation levels in DPPA3 KO overexpressing DPPA3 mutants
LINE-1 DNA methylation levels in DPPA3 KO overexpressing DPPA3 mutants
PRJEB40756 | ENA
TranscriptomicsDPPA3-HIF1a axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype (DNA methylation arrays)
Tumor relapse is linked to rapid chemoresistance and represents a bottleneck for cancer therapy success. Engagement of a reduced proliferation state is a non-mutational mechanism exploited by cancer cells to bypass therapy-induced cell death. Through combining pulse-chase experiments in engineered C...
ORGANISM(S): Homo sapiens 
2023-07-30 | E-MTAB-12892 | biostudies-arrayexpress
TranscriptomicsTbx3 controls Dppa3 levels to regulate exit from pluripotency towards mesodermal lineage
Tbx3, a member of the T-box family, plays important roles in development, stem cells, nuclear reprogramming and cancer. Loss of Tbx3 induces differentiation in mouse embryonic stem cells (mESCs). However, we show that mESCs exist in an alternate stable pluripotent state in the absence of Tbx3. In-de...
ORGANISM(S): Mus musculus 
2015-07-21 | E-GEOD-60066 | biostudies-arrayexpress
GenomicsRole of Dppa3 during primordial germ cell development II
Role of Dppa3 during primordial germ cell development II
PRJNA839021 | ENA
UnknownStructure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differences from mouse DPPA3.
Not available
S-EPMC11187062 | biostudies-literature
GenomicsThe role of Dppa3 in mESC through RNA-seq
The role of Dppa3 in mESC through RNA-seq
PRJNA813143 | ENA
GenomicsLINE-1 DNA methylation levels in DPPA3 KO overexpressing DPPA3 mutants
DPPA3 mutants were overexpressed using a doxycycline system to identify regions in DPPA3 necessary for DNA methylation maintenance suppression
ORGANISM(S): Mus musculus 
2020-10-22 | E-MTAB-9653 | biostudies-arrayexpress
UnknownDPPA3 facilitates genome-wide DNA demethylation in mouse primordial germ cells.
Not available
S-EPMC10996186 | biostudies-literature
UnknownDppa3 facilitates self-renewal of embryonic stem cells by stabilization of pluripotent factors.
Not available
S-EPMC9044575 | biostudies-literature
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