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ProteomicsHeme acts as a molecular degrader linking CRL2-FEM1B to substrate proteolysis and ferroptosis regulation in lung cancer
In this project, we sought to identify the proteins interacting with the Elongin-C/Elongin-B complex. To this end, we performed affinity purification of Elongin-C and Elongin-B tagged with FLAG-STREP and MYC, respectively. A cell line with FLAG-STREP empty vector was used as negative control. 3 biol...
ORGANISM(S): Homo sapiens (Human) 
2026-06-11 | PXD062976 | Pride
Lc-msms  dia  elongin-c  elongin-b  cul2  cullin-ring ubiquitin ligase  crl2 
UnknownBinding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C.
Not available
S-EPMC17727 | biostudies-literature
UnknownCrystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.
Not available
S-EPMC1472497 | biostudies-literature
UnknownRegulation of cytokine-inducible SH2-containing protein (CIS) by ubiquitination and Elongin B/C interaction.
Not available
S-EPMC4373541 | biostudies-literature
UnknownElongin C Contributes to RNA Polymerase II Degradation by the Interferon Antagonist NSs of La Crosse Orthobunyavirus.
Not available
S-EPMC7081911 | biostudies-literature
UnknownMolecular dynamics reveal potential effects of novel VHL variants on VHL-Elongin C binding in ccRCC patients from Eastern India.
Not available
S-EPMC12000512 | biostudies-literature
UnknownCRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.
Not available
S-EPMC6138441 | biostudies-literature
UnknownMaize Elongin C interacts with the viral genome-linked protein, VPg, of Sugarcane mosaic virus and facilitates virus infection.
Not available
S-EPMC4143955 | biostudies-literature
TranscriptomicsGene expression profiling of ElonginA knocked-down Hela cells in the presence of Doxorubicin
Transcriptional elongation factor Elongin A exhibits an activity to repress the temporary pause of RNA polymerase II (RNAPII) on the DNA template, resulting in increase of mRNA synthesis in vitro. However, actual elongation ability of Elongin A in mammalian cells has not been determined yet. To eluc...
ORGANISM(S): Homo sapiens 
2013-09-03 | E-GEOD-30432 | biostudies-arrayexpress
ProteomicsPeptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells
Inhibiting protein-protein interactions via designed peptides is a suitable strategy to block the function of important proteins in cells. The Elongin BC heterodimer (ELOB/C) is involved in transcription elongation and protein turnover. It interacts with target proteins via a so-called BC-box to mod...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD038414 | Pride
Peptide inhibition Elongin bc Cancer Prc2 Epop 
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