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TranscriptomicsGlobal gene-expression analyses of the Esrrb knockdown cells
In the murine system, Oct4, Sox2, c-Myc and Klf4 are sufficient to convert fibroblasts to induced pluripotent stem (iPS) cells that exhibit many characteristics of embryonic stem (ES) cells. Herein, we show that the orphan nuclear receptor Esrrb works in conjunction with Oct4 and Sox2 to mediate rep...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-13212 | biostudies-arrayexpress
TranscriptomicsDual knockdown of Esrrb and Sox2 in mouse embryonic stem cells
Esrrb, Sox2 or Esrrb and Sox2 were knocked down in mouse ES cells using shRNA plasmid pSUPER.puro containing shRNAs from the publications Feng et al., 2009 and Rodda et al., 2005. Knockdown was transfected into mouse ES cells using lipofectamine and then cells were selected for knockdown using purom...
ORGANISM(S): Mus musculus 
2012-11-22 | E-GEOD-34170 | biostudies-arrayexpress
ProteomicsFgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of Trophoblast Stem Cells
Esrrb is a transcription factor implicated in embryonic stem (ES) cell self-renewal, yet its knockout causes intrauterine lethality due to defects in trophoblast development. Here we show that in trophoblast stem (TS) cells, Esrrb is a downstream target of fibroblast growth factor (Fgf) signalling a...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-24 | PXD002183 | Pride
Ts cells Esrrb Self-renewal Transcription factors Lc-ms/ms 
ProteomicsNext generation unnatural monosaccharides reveal that ESRRBO GlcNAcylation enhances pluripotency of mouse embryonic stem cells
Unnatural monosaccharides such as azidosugars that can be metabolically incorporated into cellular glycans are currently used as a major tool for glycan imaging and glycoproteomic profiling. As a common practice to enhance membrane permeability and cellular uptake, the unnatural sugars are per O ac...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-09-09 | PXD015035 | Pride
1 1 3-pr2galnaz Esrrb O-glcnac 3-ac2galnaz 
ProteomicsNext generation unnatural monosaccharides reveal that ESRRBO GlcNAcylation enhances pluripotency of mouse embryonic stem cells
Unnatural monosaccharides such as azidosugars that can be metabolically incorporated into cellular glycans are currently used as a major tool for glycan imaging and glycoproteomic profiling. As a common practice to enhance membrane permeability and cellular uptake, the unnatural sugars are per O ac...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2019-09-12 | PXD014785 | Pride
1 1 3-pr2galnaz Esrrb O-glcnac 3-ac2galnaz 
TranscriptomicsMessenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells
We report nuclear receptor Esrrb's responsive genes with or without Esrrb ligand DY131 in DU145 cells. Using Esrrb-null cells, we used RNA-Seq to find Esrrb responsive genes. In addition, we tested DY131-driven Esrrb-dependent genes to test the ligand dependency of Esrrb in regulating gene expressio...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-GEOD-71208 | biostudies-arrayexpress
ProteomicsMitotic bookmarking redundancy by nuclear receptors mediates robust post-mitotic reactivation of the pluripotency network.
Mitotic bookmarking transcription factors (TFs) are thought to mediate rapid and accurate post-mitotic gene reactivation. However, the loss of individual bookmarking TFs often leads to the deregulation of only a small proportion of their mitotic targets, raising doubts on the significance and import...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-20 | PXD038950 | Pride
Nuclear receptors Pluripotency Esrrb Nr5a2 Es cells Mitotic bookmarking 
TranscriptomicsMicroarray analysis of EpiSCs undergoing reprogramming by Esrrb.
To characterize the reprogramming of epiblast stem cells (EpiSCs) into embryonic stem cells (ESCs) induced by Esrrb, we performed microarray analysis of Tet-on Esrrb EpiSCs after treatment with doxycycline (Dox).
ORGANISM(S): Mus musculus 
2018-06-01 | E-MTAB-5341 | biostudies-arrayexpress
ProteomicsESRRB Facilitates the Conversion of Trophoblast-like Stem Cells from Induced Pluripotent Stem cells by Directly Regulating KRT8 and CDX2
Porcine induced pluripotent stem cells (piPSCs) could serve as a great model system for human stem cell pre-clinical research. However, the pluripotency gene network of piPSCs, especially the function for the core transcription factor ESRRB, was poorly understood. Here, we constructed ESRRB-overexpr...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-02-17 | PXD027539 | Pride
Trophoblast stem cells (tscs) Esrrb Induced pluripotent stem cells (ipscs) Cdx2 Krt8 
GenomicsChIP-seq analysis of Esrrb, Nanog, Oct4, and Sox2 in EpiSCs undergoing reprogramming
To investigate the molecular mechanisms underlying the reprogramming of epiblast stem cells (EpiSCs) into embryonic stem cells (ESCs) induced by Esrrb, we performed ChIP-seq analysis of Esrrb, Nanog, Oct4, and Sox2 in Tet-on Esrrb EpiSCs after treatment with doxycycline (Dox).
ORGANISM(S): Mus musculus 
2018-06-01 | E-MTAB-5342 | biostudies-arrayexpress
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