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ProteomicsProtein synthesis during myoblast differentiation
Mole (MSR) and fractional (FSR) synthesis rates of proteins during C2C12 myoblast differentiation were investigated. Myoblast cultures supplemented with D2O during 0-24 h or 72-96 h of differentiation were analysed by LC-MS/MS to calculate protein FSR and MSR after samples were spiked with yeast alc...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-22 | PXD021125 | Pride
C2c12  muscle  fractional synthesis rate 
ProteomicsDeuterium oxide labeling methods for bulk and single muscle protein synthesis measures, and measures of integrated muscle protein synthesis and breakdown rates
This methodological pilot study explored the feasibility of an integrated tracer approach for simultaneous measurement of human skeletal muscle protein synthesis and breakdown during prolonged deuterium oxide (²H₂O) labelling. Four healthy men completed a five week protocol combining daily oral ²H₂O...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD078552 | Pride
Human Skeletal muscle Protein trunover 
ProteomicsHuman serum proteome dynamics in type 2 diabetes using heavy water labeling mass spectrometry
Control subjects and type 2 diabetic patients were given deuterium-labeled (heavy) water for a seven-day period and their plasma serum proteins were analyzed by high-resolution mass spectrometry. Using an in-house-developed software, fractional synthesis rates were calculated for proteins of interes...
ORGANISM(S): Homo sapiens (Human) 
2017-11-02 | PXD005755 | Pride
Proteome dynamics Mass spectrometry Serum Type 2 diabetes Heavy water T2d Human 
UnknownFractional Synthesis Rates of Individual Proteins in Rat Soleus and Plantaris Muscles.
Not available
S-EPMC7356555 | biostudies-literature
TranscriptomicsTranscription profiling of human muscle biopsies from Duchenne muscular dystrophy subjects treated with oxandrolone
Three subjects with Duchenne muscular dystrophy (8.3, 10.4, and 16.7 years old) were studied. Baseline studies included stable isotope infusion followed by gastrocnemius muscle biopsy to determine myosin heavy chain synthesis rates. RNA was isolated from the muscle biopsy as well. The subjects were ...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-1764 | biostudies-arrayexpress
ProteomicsEffect of an immune challenge and feed supplements on broiler chicken individual breast muscle protein synthesis
Optimization of broiler chicken breast muscle protein accretion is key for the efficient production of poultry meat, whose demand is steadily increasing. In a context where antimicrobial growth promoters use is being restricted, it is important to find alternatives as well as to characterize the eff...
ORGANISM(S): Gallus gallus (Chicken) 
2024-04-04 | PXD044325 | Pride
Chicken Citrus Fsr Muscle 
UnknownProtein fractional synthesis rates within tissues of high- and low-active mice.
Not available
S-EPMC7703944 | biostudies-literature
ProteomicsC2C12 PEA and Ibuprofen LC-MS/MS
This study investigated the effects of palmitoylethanolamide (PEA) and ibuprofen (IBU) treatment on the dynamic regulation of the skeletal muscle proteome using a C2C12 myotube model. Differentiated myotubes were treated for 36 hours with vehicle control (VC), PEA (10 µM), or IBU (100 µM). Dynamic p...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-25 | PXD069882 | Pride
C2c12 Muscle Lcms/ms 
UnknownSubstitution of Dietary Sulfur Amino Acids by dl-2-Hydroxy-4-Methylthiobutyric Acid Reduces Fractional Glutathione Synthesis in Weaned Piglets.
Not available
S-EPMC7138682 | biostudies-literature
UnknownPredictors of muscle protein synthesis after severe pediatric burns.
Not available
S-EPMC4376006 | biostudies-literature
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