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GenomicsGLA
GLA
PRJEB71791 | ENA
GenomicsSyngergistic Anti-tumor Effects between GLA and X-ray Radiation
Syngergistic Anti-tumor Effects between GLA and X-ray Radiation
PRJNA739655 | ENA
GenomicsIntratumoral injection of TLR4 agonist GLA in A20 tumor model
Intratumoral injection of TLR4 agonist GLA in A20 tumor model
PRJNA632482 | ENA
OtherSyngergistic Anti-tumor Effects between GLA and X-ray Radiation
Nanostring gene expression analysis using tumors from mice treated with GLA, X-ray radiation or the combination of GLA and radiation showed that the combination of GLA and radiation has synergistic effect in modulating the tumor micronenvironment.
ORGANISM(S): Mus musculus 
2021-12-22 | GSE178553 | GEO
ProteomicsMitochondrial stress in GLA mutants Zebrafish is independent of globotriaosylceramide accumulation
Fabry disease (FD) is a hereditary lysosomal storage disorder caused by mutations in GLA gene resulting in reduction or lack of α-galactosidase A activity. In humans, enzymatic deficiency leads to accumulation of globotriaosylceramide (Gb3) and other glycosphingolipids in lysosomes. Current therapie...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2023-10-24 | PXD035409 | Pride
Alpha-galactosidase a/ fabry disease/ lysosome/ mitochondrial activity/ proteomic approach 
GenomicsRole of Matrix Gla Protein in Brown Adipose Tissue Development
Role of Matrix Gla Protein in Brown Adipose Tissue Development
PRJNA975609 | ENA
ProteomicsProteomic anlaysis of Fabry iPSC derived cardiomyocytes treated with GLA modRNA
Recent studies in non-human model systems have shown therapeutic potential of modified mRNA (modRNA) treatments for lysosomal storage diseases. Here, we assessed the efficacy of a modRNA treatment to restore the expression of the α-galactosidase (GLA) gene in a human cardiac model generated from ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD038361 | Pride
Cardiomyocytes Ipsc Fabry 
TranscriptomicsGLA and profiling of proteasome, Spt23 and Mga2
The proteasome can regulate transcription through proteolytic processing of transcription factors and via gene locus binding, but few targets of proteasomal regulation have been identified. Using genome-wide location analysis and transcriptional profiling in Saccharomyces cerevisiae, we have establ...
ORGANISM(S): Saccharomyces cerevisiae 
2006-02-28 | E-GEOD-4272 | biostudies-arrayexpress
GenomicsPanicum hallii cultivar:GLA-1-F
Panicum hallii GLA-1-F Resequencing
PRJNA1326655 | ENA
ProteomicsMatrix Gla Protein acts as a driver of stemness and tumor initiation in ovarian cancer
Ovarian cancer (OC) displays the highest mortality among gynecological tumors, mainly due to early peritoneal dissemination, the high frequency of tumor relapse following primary debulking and the development of chemoresistance. All these events are thought to be initiated and sustained by a subpopu...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037543 | Pride
Exploris 480  matrix gla protein  ovarian cancer  cancer stem cells  tumor initiation  hedgehog pathway 
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