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MetabolomicsStable Isotope–Assisted Plant Metabolomics: Combination of Global and Tracer-Based Labeling for Enhanced Untargeted Profiling and Compound Annotation
Untargeted approaches and thus biological interpretation of metabolomics results are still hampered by the reliable assignment of the global metabolome as well as classification and (putative) identification of metabolites. In this work we present an liquid chromatography-mass spectrometry (LC-MS)-b...
2020-02-09 | MTBLS1217 | MetaboLights
TranscriptomicsGlobal identification of yeast chromosome interactions using genome conformation capture
The objective of this study was to determine the global chromosomal interaction map for exponentially growing Saccharomyces cerevisiae cells using Genome Conformation Capture. Interactions between chromosomes were identified within a population of yeast cells growing exponentially in a semi-defined ...
ORGANISM(S): Saccharomyces cerevisiae 
2009-07-21 | E-GEOD-13648 | biostudies-arrayexpress
ProteomicsAn SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck
While ATP-site inhibitors for protein-tyrosine kinases are often effective drugs, their clinical utility can be limited by off-target activity and acquired resistance mutations due to the conserved nature of the ATP-binding site. However, combining ATP-site and allosteric kinase inhibitors can overc...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054878 | Pride
Hck  hdx-ms  hydrogen/deuterium exchange mass spectrometry  allosteric modulator  global conformation 
GenomicsOncogene-Mediated Alterations in Chromatin Conformation
Emerging evidence suggests that chromatin adopts a non-random three-dimensional (3D) topology and that the organization of genes into structural hubs and domains affects their transcriptional status. How chromatin conformation changes in diseases such as cancer is poorly understood. Moreover, how on...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-37752 | biostudies-arrayexpress
TranscriptomicsGlobal spatial organization of M-NM-3 proteobacterial nucleoids is determined by specific long-range interactions (E. coli)
GCC was used to determine the structure of E. coli grown in LB or treated with SHX. The bacterial genome is highly condensed into a nucleoid structure. Here we present global analyses of the genome spatial organization for two M-NM-3-proteobacteria: Escherichia coli and Pseudomonas aeruginosa by Ge...
ORGANISM(S): Escherichia coli 
2013-05-02 | E-GEOD-40603 | biostudies-arrayexpress
TranscriptomicsA comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
The inactive X chromosome (Xi) serves as a model to understand gene silencing on a global scale. Here, we perform identification of direct RNA interacting proteins? (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing. We discover multiple classes of inte...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-67516 | biostudies-arrayexpress
OtherGlobal identification of yeast chromosome interactions using genome conformation capture
The objective of this study was to determine the global chromosomal interaction map for exponentially growing Saccharomyces cerevisiae cells using Genome Conformation Capture. Interactions between chromosomes were identified within a population of yeast cells growing exponentially in a semi-defined ...
ORGANISM(S): Saccharomyces cerevisiae 
2009-07-21 | GSE13648 | GEO
UnknownGlobal conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing.
Not available
S-EPMC12557722 | biostudies-literature
GenomicsGlobal early replication disrupts gene expression and chromatin conformation in a single cell cycle: transcription
Global early replication disrupts gene expression and chromatin conformation in a single cell cycle: transcription
PRJNA820013 | ENA
UnknownSelective Proteolysis to Study the Global Conformation and Regulatory Mechanisms of c-Src Kinase.
Not available
S-EPMC7254491 | biostudies-literature
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