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ProteomicsSubstrate specificity divergence of granzyme tryptases.
Elucidating the true physiological functions of granzymes has been challenging since the origin of the granzyme studied, the use of non-physiological granzyme concentrations and the interspecies use of granzymes, with extrapolation of all these data to orthologous granzymes has led to inconsistencie...
ORGANISM(S): Homo sapiens (Human) 
2015-09-30 | PXD000570 | Pride
Proteomics Granzyme N-terminal cofradic Protease Specificity profile 
ProteomicsGranzyme B cleaves Tenascin-C to release its C-terminal FBG-like domain into the synovial fluid of patients with rheumatoid arthritis
Raw files and search engine files for the proteomics data resulting from the digestion of Tenascin-C by Granzyme B
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-20 | MSV000094138 | MassIVE
GenomicsBulk RNA-seq of human synovial fluid CD8 T cells sorted by Granzyme B vs Granzyme K expression
Bulk RNA-seq of human synovial fluid CD8 T cells sorted by Granzyme B vs Granzyme K expression
PRJNA835733 | ENA
ProteomicsHuman Differentiated SH-SY5Y neuroblastoma cells treated with Granzyme K
Human Differentiated SH-SY5Y neuroblastoma cells treated with 150 nM GrK alone or together with 100 nM SCH79797 PAR-1 inhibitor to evaluate the impact of granzyme K (GrK) on neuronal functions.
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD064640 | Pride
Neuroblastoma Alzheimer's disease Granzyme k Sh-sy5y 
ProteomicsGrM - Human and mouse granzyme M display divergent and species-specific substrate specificities
Complementary positional proteomics of human and mouse granzyme M treated K-562 lysates
2012-05-23 | PRD000347 | Pride
ProteomicsGranzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis in cancer cells
Cytotoxic lymphocyte protease granzyme M (GrM) is a potent inducer of tumor cell death in vitro and in vivo. The apoptotic phenotype and mechanism by which it induces cell death however, remain poorly understood and controversial. Here, we show that GrM-induced cell death was largely caspase-depende...
ORGANISM(S): Homo sapiens (Human) 
2013-11-27 | PXD000252 | Pride
Human Lc-msms Granzyme m 
GenomicsProfiling of Granzyme B Secreting B cells
Profiling of Granzyme B Secreting B cells
PRJNA517914 | ENA
GenomicsGranzyme K CD8 T cells form a core population in inflamed human tissue
Granzyme K CD8 T cells form a core population in inflamed human tissue
PRJNA985378 | ENA
GenomicsGranzyme K CD8 T cells form a core population in inflamed human tissue
Granzyme K CD8 T cells form a core population in inflamed human tissue
PRJNA985379 | ENA
GenomicsCytotoxic Granzyme C Expressing ILC1s Contribute to Antitumor Immunity and Neonatal Autoimmunity
Cytotoxic Granzyme C Expressing ILC1s Contribute to Antitumor Immunity and Neonatal Autoimmunity
PRJNA806957 | ENA
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