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ProteomicsA helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis to promote parasite chronicity
The molecular mechanisms by which worm parasites evade host immunity are incompletely understood. In a mouse model of chronic intestinal helminth infection, we identify helminthic glutamate dehydrogenase (heGDH) as an essential factor for parasite chronicity by using antibody mediated neutralization...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD044102 | Pride
A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis to promote parasite chronicity 
ProteomicsGlycosylation of somatic extracts and secretome in the infective stage of the helminth Fasciola hepatica
Fasciola hepatica is a global helminth parasite of humans and their livestock. The invasive stage of the parasite, the newly excysted juvenile (NEJs), relies on glycosylated excretedsecreted (ES) products and surface/somatic molecules to interact with host cells and tissues and to evade the host's i...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2024-01-26 | PXD045488 | Pride
Glycoproteomics Orbitrap Parasites Glycosylation Lc-ms/ms 
GenomicsChromatin Landscape of Macrophages Following Helminth Enzyme Exposure Targeting Prostaglandin Synthesis
Chromatin Landscape of Macrophages Following Helminth Enzyme Exposure Targeting Prostaglandin Synthesis
PRJNA1081279 | ENA
GenomicsGene expression profile of Macrophages Following Helminth Enzyme Exposure Targeting Prostaglandin Synthesis
Gene expression profile of Macrophages Following Helminth Enzyme Exposure Targeting Prostaglandin Synthesis
PRJNA1081278 | ENA
UnknownHelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritization.
Not available
S-EPMC3132748 | biostudies-literature
UnknownGlycan Complexity and Heterogeneity of Glycoproteins in Somatic Extracts and Secretome of the Infective Stage of the Helminth Fasciola hepatica.
Not available
S-EPMC10755494 | biostudies-literature
UnknownAn integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host.
Not available
S-EPMC2722771 | biostudies-literature
GenomicsChromatin Landscape of Macrophages Following Helminth Enzyme Exposure Targeting Prostaglandin Synthesis
The molecular mechanisms by which worm parasites evade host immunity are incompletely understood. In a mouse model of chronic intestinal helminth infection, we identify helminthic glutamate dehydrogenase (heGDH) as an essential factor for parasite chronicity by using antibody mediated neutralization...
ORGANISM(S): Homo sapiens 
2025-03-15 | GSE259349 | GEO
ProteomicsThe extracellular vesicles of the helminth pathogen, Fasciola hepatica: biogenesis pathways and cargo molecules involved in parasite pathogenesis
We reveal that whilst the molecular “machinery” required for EV biogenesis is constitutively expressed across the intra-mammalian development stages of the parasite, the cargo molecules packaged within the EVs are regulated, most likely to facilitate the parasites migration through host tissue and t...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2015-10-14 | PXD002570 | Pride
Helminth Proteomics Extracellular vesicle Exosome Fasciola Transcriptomics Secretome 
TranscriptomicsGene expression profile of Macrophages Following Helminth Enzyme Exposure Targeting Prostaglandin Synthesis
The molecular mechanisms by which worm parasites evade host immunity are incompletely understood. In a mouse model of chronic intestinal helminth infection, we identify helminthic glutamate dehydrogenase (heGDH) as an essential factor for parasite chronicity by using antibody mediated neutralization...
ORGANISM(S): Homo sapiens 
2025-03-15 | GSE259350 | GEO
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