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MetabolomicsComparative metabolomics analysis reveals high-altitude adaptations in a toad-headed viviparous lizard, Phrynocephalus vlangalii
Extreme environmental conditions at high altitude, such as hypobaric hypoxia, low temperature, and strong UV radiation, pose a great challenge to the survival of animals. Although the mechanisms of adaptation to high-altitude environments have attracted much attention for native plateau species, the...
2024-01-16 | MTBLS6900 | MetaboLights
MetabolomicsIsoquercitrin alleviates subchronic high-altitude hypoxia-induced myocardial injury by regulating mitochondrial energy metabolism and maintaining immune–inflammatory homeostasis
High-altitude hypoxia induces myocardial metabolic disorders, structural remodeling, and functional impairment, which threaten the health of highland populations. The interventional effects and molecular mechanisms of isoquercitrin (IQ), a natural flavonoid with cardiovascular protective activity, a...
2026-07-29 | MTBLS15192 | MetaboLights
MetabolomicsMulti-omics Analysis Reveals New Insights into Yak Lung Fibrosis Mechanisms Under High-Altitude Adaptation

The lung of yak is an important adaptive organ in the cold and low oxygen environment. Hypoxia can induce the pathological manifestations of pulmonary fibrosis in yak, but there was no study on hypoxia induced pulmonary fibrosis in yak. In this study full target metabolomics were used to conduct ...

2025-07-07 | MTBLS11648 | MetaboLights
ProteomicsDeep crotonylproteomics analysis of high-altitude exposure hearts in mice
Background: The potential molecular mechanisms underlying acute adaptation and chronic remodeling of cardiac structure and function in response to high altitude are not yet fully understood. This study aims to investigate changes in the crotonylproteome in the hearts of mice exposed to high altitude...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD044178 | Pride
Crotonylation  heart  high altitude  metabolism  muscle 
ProteomicsAlterations of human plasma proteome profile on adaptation to high-altitude hypobaric hypoxia
For individuals migrating to or residing permanently at high-altitude regions, environmental hypobaric hypoxia is a primary challenge which induces several physiological or pathological responses. It is well documented that human beings adapt to hypobaric hypoxia via some protective mechanisms, such...
ORGANISM(S): Homo sapiens (Human) 
2019-03-27 | PXD012221 | Pride
Proteomics  high altitude  hypobaric hypoxia  complement and coagulation cascades  antioxidant  glycolysis. 
TranscriptomicsGene expression profiling under exposure to high altitude hypoxic environment
Understanding molecular mechanism associated with high altitude exposure during acclimatization/adaptation/maladaptation. Data reveals specific components of the complex molecular circuitry underlying high altitude pulmonary edema. Individualized outcome prediction were constructed through expressio...
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-52209 | biostudies-arrayexpress
ProteomicsIdentification of novel urine proteomic biomarkers for high stamina in high-altitude adaptation
Ascending to high-altitude of non-high-altitude natives showed rapidly declined physical ability, but some with high-altitude adaptability were still able to maintain a high level. Our goal was to find urine biomarkers that could be used to assess people for high-altitude hypoxia adaptation with hig...
ORGANISM(S): Human Parechovirus Strain T82-0169 
2023-02-02 | PXD039791 |
TranscriptomicsAffymetrix SNP array data for 31 Tibetan samples
This data was used to identify regions of the genome that have undergone positive selection in a high-altitude Tibetan population. Affymetrix SNP arrays were used to genotype DNA extracted from blood samples. This data was used to perform genome-wide scans of positive selection in a native high-alt...
ORGANISM(S): Homo sapiens 
2010-07-22 | E-GEOD-21661 | biostudies-arrayexpress
UnknownToward the Discovery of a Novel Class of Leads for High Altitude Disorders by Virtual Screening and Molecular Dynamics Approaches Targeting Carbonic Anhydrase.
Not available
S-EPMC9104310 | biostudies-literature
GenomicsHigh-altitude permafrost soil
High-altitude permafrost soil Raw sequence reads
PRJNA633441 | ENA
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