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TranscriptomicsInsulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb
In this study, we demonstrate that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from hippocampus and olfactory bulb. Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampus and olfactory bulb-derived ...
ORGANISM(S): Rattus norvegicus 
2012-03-14 | E-GEOD-27956 | biostudies-arrayexpress
UnknownSpatial encoding in dorsomedial prefrontal cortex and hippocampus is related during deliberation.
Not available
S-EPMC7606780 | biostudies-literature
GenomicsIdentification transcriptomic changes in the HPC after striatal neuroinflammation
Identification transcriptomic changes in the HPC 24h after LPS injection in the striatum
PRJEB50635 | ENA
TranscriptomicsPrenatal alcohol exposure alters steady-state and activated gene expression in the adult rat brain
Background: Prenatal alcohol exposure (PAE) is associated with alterations in numerous physiological systems, including the stress and immune systems. We have previously shown that PAE increases the course and severity of arthritis in an adjuvant-induced arthritis (AA) model. While the molecular mec...
ORGANISM(S): Rattus norvegicus 
2014-11-21 | E-GEOD-63561 | biostudies-arrayexpress
ProteomicsL-lactate induced proteomic changes in rat hippocampus
Rats were anesthetized with sodium pentobarbital (50 mg/kg, i.p.) and placed in a stereotaxic instrument (Kopf instrument). After exposing the skull, bilateral craniotomy (0.5 - 0.8 mm holes, 4 mm posterior to bregma and 2.6 mm lateral from midline) was done. In one group of rats (Lactate group), ea...
ORGANISM(S): Rattus Norvegicus 
2023-02-23 | PXD039121 | JPOST Repository
ProteomicsProteomic signatures of Psychosocial Stress and Western Diet- driven Mitochondrial Dysfunction in Frontal Cortex and Hippocampus
Chronic Stress and Western diet are major risk factors for affective disorders, however their biological interactions remain unclear. This study examined the neurochemical, mitochondrial, metabolic, behavioural and proteomic effects of a chronic stress paradigm (2h/day for 2 weeks) in male C57bl/6 m...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-25 | PXD074187 | Pride
Depression Mitochondria Stress Mouse Respiration Synaptogenesis Anxiety Western diet Co-morbidity 
UnknownImpairment of catecholamine systems during induction of long-term potentiation at hippocampal CA1 synapses in HPC-1/syntaxin 1A knock-out mice.
Not available
S-EPMC6621322 | biostudies-literature
ProteomicsProteomic analysis of a rat streptozotocin model shows dysregulated biological pathways implicated in Alzheimer’s Disease
Alzheimer’s Disease (AD) is an age-related neurodegenerative disorder characterized by progres-sive memory loss and cognitive impairment, affecting 35 million individuals worldwide. Intracer-ebroventricular (ICV) injection of low to moderate doses of STZ in adult male Wistar rats can re-produce clas...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-06-22 | PXD048720 | Pride
Pre-frontal cortex (pfc)  hippocampus (hpc)  streptozotocin 
TranscriptomicsChronic Intermittent Ethanol by vapor chamber gene expression time-course in hippocampus [HPC]
Lasting behavioral and physiological changes such as abusive consumption, dependence, and withdrawal are characteristic features of alcohol use disorders (AUD). Mechanistically, persistent changes in gene expression are hypothesized to contribute to these brain adaptations leading to ethanol toxicit...
ORGANISM(S): Mus musculus 
2016-04-15 | GSE72514 | GEO
UnknownTheta-paced stimulation of the thalamic nucleus reuniens entrains mPFC-HPC oscillations and facilitates the acquisition of extinction memories.
Not available
S-EPMC12363944 | biostudies-literature
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