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MetabolomicsHyaluronan catabolism supports the peritoneal disseminated metastasis of cancer through the glucuronic acid pathway
When disseminated into the peritoneal cavity at the very early stage, cancer cells must adapt to the glucose- and oxygen-limited environment in peritoneal fluid, yet the key molecular regulators remain undefined. Here, we reveal that early disseminated OC cells are ingeniously utilize hyaluronic aci...
2026-07-10 | MTBLS15007 | MetaboLights
TranscriptomicsTranscription profiling of fibroblast-like synovial cells from normal adult horse following treatment with hyaluronan and challenged with lipopolysaccharide
Greater than 95% confluent (Day 0) fibroblast-like synovial cells from the hind limbs (pelvic limb) of normal adult horses were allocated in triplicate to one of 4 groups:

(group 1) unchallenged;
(group 2) LPS-challenged;
(group 3) LPS-challenged following pre-treatment and susta...
ORGANISM(S): Equus caballus 
2007-01-10 | E-MEXP-940 | biostudies-arrayexpress
TranscriptomicsThe effect of very-high-molecular-mass hyaluronan (vHMM-HA) on CD44-overexpressing IMR90 cells
Naked mole-rat skin fibroblasts (NSF) produces vHMM-HA. Although NSF-HA has been shown to suppress NSF transformation, it is still unclear if exceptional polymer length of vHMM-HA is important for its functions. Here, we compared the effect of intact control NSF-HA (cNSF-HA) ) on the transcriptome o...
ORGANISM(S): Homo sapiens 
2020-04-25 | E-MTAB-8943 | biostudies-arrayexpress
ProteomicsThe effect of very-high-molecular-mass hyaluronan (vHMM-HA) on CD44 protein-protein interactions.
Naked mole-rat skin fibroblasts (NSF) produces vHMM-HA. Although NSF-HA has been shown to suppress NSF transformation, it is still unclear if exceptional polymer length of vHMM-HA is important for its functions. Here, we compared the effect of intact control NSF-HA (cNSF-HA) and partially fragmented...
ORGANISM(S): Homo sapiens (Human) 
2020-03-24 | PXD013445 | Pride
Naked mole rat / hyaluronan / cd44 
TranscriptomicsRNAseq of epidermis reconstructed from TSG-6-/- and TSG-6+/+ immortalized N/TERT keratinocytes and stimulated or not with interleukins 4 and 13 for 48h
TNFα-stimulated gene 6 (TSG-6) is an anti-inflammatory protein. In human epidermis, TSG-6 is secreted in extracellular matrix where it interacts with hyaluronan (HA). However, their functions are not well understood. In this study, immortalized N/TERT keratinocytes were edited by CRISPR/Cas9, used t...
ORGANISM(S): Homo sapiens 
2021-12-30 | E-MTAB-10095 | biostudies-arrayexpress
UnknownRegulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts.
Not available
S-EPMC4692219 | biostudies-literature
TranscriptomicsDeletion of hyaluronan synthase 3 inhibits neointimal hyperplasia
Affymetrix Mouse Gene 2.0 ST Gene Expression Microarrays were used to analyze differentially expressed genes after carotid artery ligation. The aim of this experiment was to detect genes regulated in Has3 deficient as compared to wildtype controls that might be involved in neointimal hyperplasia. Ne...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-70410 | biostudies-arrayexpress
GenomicsThe effect of very-high-molecular-mass hyaluronan (vHMM-HA) on IMR90 transcriptome
The effect of very-high-molecular-mass hyaluronan (vHMM-HA) on IMR90 transcriptome
PRJNA480072 | ENA
ProteomicsProteomic analysis of Bacteroides thetaiotaomicron and Bacteroides acidifaciens following cultivation on hyaluronan and a standard substrate
This project investigates proteomic adaptations of Bacteroides thetaiotaomicron and Bacteroides acidifaciens in response to hyaluronan as the sole glycosaminoglycan carbon source. Both species were cultivated in a standard medium and in a hyaluronan-based minimal medium, and their proteomes were ana...
ORGANISM(S): Bacteroides acidifaciens Bacteroides thetaiotaomicron 
2026-02-23 | PXD067466 | Pride
Lc-ms Timstof pro Hyaluronan  bacteroides thetaiotaomicron  bacteroides acidifaciens  glycosaminoglycan metabolism 
GenomicsThe effect of very-high-molecular-mass hyaluronan (vHMM-HA) on CD44-overexpressing IMR90 cells
The effect of very-high-molecular-mass hyaluronan (vHMM-HA) on CD44-overexpressing IMR90 cells
PRJEB37814 | ENA
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