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ProteomicsPyrin oligomerization nucleates antiviral IFI16 sensing of herpesvirus DNA
The formation of multimerized protein assemblies has emerged as a core component of immune signal amplification, yet the biochemical basis of this phenomenon remains unclear for many mammalian proteins within host defense pathways. The interferon-inducible protein 16 (IFI16) is a viral DNA sensor th...
ORGANISM(S): Homo sapiens (Human) 
2019-07-10 | PXD014349 | Pride
Ifi16 Ip-ms Dna sensing Hsv-1 Oligomerization 
TranscriptomicsTranscriptional response to drug-induced oligomerization of the AIM2-like receptors IFI16, PYHIN1, and MNDA.
We explored ALR function in a ligand-independent manner using a drug-inducible dimerization system in which ALRs were tagged with two FV domains that rapidly oligomerize upon addition of the drug AP1 We found that oligomerization of IFI16, PYHIN1, or MNDA did not result in any significant gene expre...
ORGANISM(S): Homo sapiens 
2016-05-31 | E-GEOD-80598 | biostudies-arrayexpress
ProteomicsFAM135B deficiency inhibits cytotoxic T cell activity in triple-negative breast cancer by blocking the IFI16-dependent STING pathway
FAM135B interacts with IFI16, inhibiting its ubiquitination and proteasomal degradation by competitively blocking its binding to the E3 ligase TRIM21, thereby initiating the IFI16-dependent STING signaling, ultimately leading to increased cytotoxic T cell activity.
ORGANISM(S): Homo Sapiens 
PXD068216 |
GenomicsInnate immune sensing of influenza virus through IFI16 promote pyroptosis.
Innate immune sensing of influenza virus through IFI16 promote pyroptosis.
PRJNA687234 | ENA
ProteomicsSystematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity
Rapid and dynamically shifting protein-protein interactions (PPIs) underlie the capacity of cells to recognize viral infections and ignite the downstream cascades that constitute the innate-immune response. Herpesviruses share an ancient history of coevolution with their hosts and have developed rec...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2021-05-11 | PXD023167 | Pride
Thermal proteome profiling  herpes simplex virus 1  protein complexes  protein interactions  ifi16  dna sensing  dna-pk  dna damage response  innate immunity 
ProteomicsIFI16 phase separation via multi-phosphorylation drives innate immune signaling
Fractionaion of nuclear periphery and core, followed by DDA in primary HFFs at 1 hour post infection with ICP0-RF HSV-1; IP-PRM of IFI16 in primary HFFs at 1 hpi; in vitro kinase assay with IFI16 and select kinases and quantification on phosphorlyated peptides by PRM.
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-05-22 | PXD034348 | Pride
Human Ptm Hsv-1 
GenomicsEffect of IFI16 on cGAS-STING pathway
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
PRJEB18609 | ENA
TranscriptomicsInnate immune sensing of influenza virus through IFI16 promote pyroptosis.
We report that IFI16, which was previously identified as a cytosolic DNA sensor, is essential for the activation of programmed cell death pathways in IAV infected cells. We have identified IFI16 as an innate immune sensor of the influenza A virus. We find that IFI16 recognizes viral genomic RNA upon...
ORGANISM(S): Homo sapiens 
2021-12-31 | GSE163705 | GEO
GenomicsIFI16-mediated cellular senescence drives HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma
IFI16-mediated cellular senescence drives HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma
PRJNA1144925 | ENA
UnknownEMCV VP2 degrades IFI16 through Caspase-dependent apoptosis to evade IFI16-STING pathway.
Not available
S-EPMC11571899 | biostudies-literature
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