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TranscriptomicsIL-33 induces a hypo-responsive human mast cell phenotype
Interleukin-33 (IL-33) is elevated in afflicted tissues of patients with mast cell-dependent chronic allergic diseases. Based on its acute effects on mouse mast cells (MCs), IL-33 is thought to play a role in the pathogenesis of allergic disease through MC activation. However, the manifestations of ...
ORGANISM(S): Mus musculus 
2013-02-06 | E-GEOD-39382 | biostudies-arrayexpress
TranscriptomicsIL-33 activates tumor stroma to promote intestinal polyposis
Tumor epithelial cells develop within a microenvironment consisting of extracellular matrix, growth factors, and cytokines produced by non-epithelial stromal cells. In response to paracrine signals from tumor epithelia, stromal cells modify the microenvironment to promote tumor growth and metastasis...
ORGANISM(S): Homo sapiens 
2015-04-29 | E-GEOD-62518 | biostudies-arrayexpress
TranscriptomicsPeri-alloHCT IL-33 administration expands recipient T regulatory cells that protect mice against acute GvHD
Graft-versus-Host Disease (GvH) is the excessive inflammatory response by mature T cells contained in the graft during bone marrow transplantation. The allogeneic T cells recognize self-antigens as foreign and systemically attack multiple organs mostly with epithelial structures such as the skin, li...
ORGANISM(S): Mus musculus 
2016-06-27 | E-MTAB-4677 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of confluent human umbilical vein endothelial cells to stimulation with the related cytokines interleukin-1b or interleukin-33.
The similar response of endothelial cells to exogenous IL-33 or IL-1M-NM-2 prompted us to compare the genome-wide transcription profile of confluent human umbilical vein endothelial cell (HUVEC) cultures after 4 hours exposure to IL-33 or IL-1M-NM-2. Analysis of these data revealed a striking simila...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-37624 | biostudies-arrayexpress
TranscriptomicsHuman ILC2 cells stimulated with IL-25, IL-33, or TSLP
ILC2 cells are a newly described cell type whose biology and contribution to disease are poorly understood. ILC2 cells are activated by allergens, viral infection, and/or epithelial damage via IL-33 and IL-25. ILC2 cells require IL-2, IL-7, IL-25 and IL-33 for their survival and expansion. In mice, ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-45458 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of mouse group 2 innate lymphoid cells (ILC2s) cultured with IL-33, IFN-g, and IL-27
Purpose: We found that IFN-g and IL-27 had suppressive effects on ILC2s cultured with IL-33. The goal of this study is to clarify the expressions of RNA induced by IFN-g and IL-27 in ILC2s. Methods: ILC2s were isolated from fat-asociated lymphid clusters (FALC) of wild-type mice. They were cultured ...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-73272 | biostudies-arrayexpress
ProteomicsProteomic analysis of the extracellular and intracellular role of IL-33 in primary human endothelial cells (IL-33 knockdown by siRNA)
IL-33 is a nuclear cytokine from the IL-1 family that plays important roles in health and disease. Under healthy conditions, IL-33 is constitutively expressed to high levels in the nucleus of producing cells in various human and mouse tissues. The extracellular function of IL-33 cytokine has been we...
ORGANISM(S): Homo sapiens (Human) 
2016-10-12 | PXD004141 | Pride
Cytokine Inflammation Endothelial cells Human Fractionation Shotgun Il-33 Huvec 
TranscriptomicsRole of IRAKM in IL-33-induced dendritic cell activation
To gain additional insight into the role of IRAKM in dendritic cell activation in response to IL-33 challenge, we profiled transcriptomes of mouse DC2.4 dendritic cell lines with or without IRAKM following IL-33 treatment in vitro. IRAKM-sufficient and deficient DC2.4 cells were cultured overnight i...
ORGANISM(S): Mus musculus 
2015-03-03 | E-GEOD-66431 | biostudies-arrayexpress
TranscriptomicsIL-33 markedly induces murine eosinophil gene transcription via autocrine IL-4-dependent and -independent mechanisms
Eosinophils are major effector cells in type 2 inflammatory responses and become activated in response to IL-4 and IL-33, yet the molecular mechanism remains unclear. We examined the direct effect of these cytokines on eosinophils and demonstrated that murine eosinophils respond to IL-4 and IL-33 by...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-43660 | biostudies-arrayexpress
ProteomicsQuantitative phosphoproteomic analysis of IL-33 mediated signaling
Interleukin-33 (IL-33) is a novel member of the IL-1 family of cytokines that plays diverse roles in the regulation of immune responses. IL-33 exerts its effects by binding to a heterodimeric receptor complex consisting of interleukin-1 receptor like 1 (IL1RL1) and an accessory receptor protein IL-1...
ORGANISM(S): Mus musculus (Mouse) 
2015-01-29 | PXD000984 | Pride
Cytokine Danger signals Inflammation 
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