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Through their functional diversification, CD4+ T cells play key roles in both driving and constraining immune-mediated pathology. Transcription factors are critical in the generation and maintenance of cellular diversity and negative regulators antagonistic to alternate fates often act in conjunctio...
ORGANISM(S): Mus musculus 
Whether epidermal factors play a primary role in immune-mediated skin diseases such as psoriasis is unknown. We now show that the pro-differentiation transcription factor Grainyhead-like 3 (GRHL3), essential during epidermal development but dispensable in adult skin homeostasis, is required for barr...
ORGANISM(S): Mus musculus 
Transcriptional differences between canine cutaneous epitheliotropic lymphoma and immune-mediated dermatoses
Staphylococcus aureus is a global health threat that can cause a multitude of diseases in many different areas of the body and is the leading cause of skin infections. This bacterium can produce a variety of proteins that contribute to virulence and disease progression. These virulence factors inclu...
ORGANISM(S): Staphylococcus Aureus Subsp. Aureus Usa300 (ncbitaxon:367830) 
2024-05-14 | MSV000094753 | MassIVE
Disulfiram mediated modulation of lung immune response during M. tuberculosis infection
Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice
The role of FoxP3+ regulatory T (Treg) cells in the maintenance of immunological tolerance is well established. Recently, genome-wide association studies (GWAS) in humans have associated polymorphisms within the BACH2 locus encoding the transcription factor BTB and CNC homology 1, basic leucine zipp...
ORGANISM(S): Mus musculus 
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