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MetabolomicsMetabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs with high efficiency in chemically defined and xeno-free conditions. Despi...
2018-04-24 | MTBLS425 | MetaboLights
Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
MetabolomicsMetabolomic analysis of mouse embryonic fibroblasts, embryonic stem cells, and induced pluripotent stem cells
Not available
ORGANISM(S): Mus musculus 
ST000003 | MetabolomicsWorkbench
ProteomicsEndogenous THBS1 is C-mannosylated by human induced pluripotent stem cells.
We used a human thrombospondin-1 (THBS1) fragment comprising thrombospondin type 1 repeats (TSRs) 1 to 3, which was recombinantly expressed in HEK 293T cells and digested with AspN to determine chromatographic retention times and to optimise MS parameters. We detected two peptides from TSR2 and TSR3...
ORGANISM(S): Homo Sapiens 
2021-05-12 | PXD024117 | panorama
ProteomicsHuman iPS cell proteome
Rapid and deep profiling of human induced pluripotent stem cell proteome analysis by one-shot nano LC-MS/MS with meter-scale monolithic silica capillary columns.
ORGANISM(S): Homo Sapiens (human) 
2016-06-20 | PXD004528 | JPOST Repository
ProteomicsQuantitative proteomics for efficient differentiation of human induced pluripotent stem cells into neural stem cells using data independent acquisition mass spectrometry.
Human induced pluripotent stem cells were differentiated into NSC for 7 days. Cells on days 0, 1, 2, 3, 5 and 7 of differentiation (2.0 × 10⁶) were washed twice with DPBS (−) and then mixed with 100 μL of dissolution buffer consisting of 12 mM sodium deoxycholate, 12 mM N-lauroylsarcosine, 100 mM Tr...
ORGANISM(S): Homo Sapiens (human) 
2022-06-27 | PXD034925 | JPOST Repository
TranscriptomicsscRNA-seq to investigate endoderm differentiation from induced human pluripotent stem cells
Single-cell RNA-seq (scRNA-seq) on nocodazole and DMSO treated cells before and after differentiation into endoderm. hPSC colonies were treated with DMSO or 100ng/ml nocodazole for 16 hours and induced to differentiate into definitive endoderm for three days. Single cells were subsequently collected...
ORGANISM(S): Homo sapiens 
2019-02-09 | E-MTAB-7008 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human hepatic cells derived from foreskin fibroblast cell line and from embryonic stem cells.
Reprogrammed somatic cells offer a valuable source of pluripotent cells that have the potential to differentiate into many cells types and provide a new tool for regenerative medicine. In the present study we differentiated induced pluripotent stem cells (iPS cells) into hepatic cells. We first show...
ORGANISM(S): Homo sapiens 
2009-08-07 | E-GEOD-14897 | biostudies-arrayexpress
TranscriptomicsErythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin
Epigenetic memory in induced pluripotent stem cells (iPSCs), with regards to their somatic cell type of origin, might lead to variations in their differentiation capacities. In this context, iPSCs from human CD34+ hematopoietic stem cells (HSCs) might be more suitable for hematopoietic differentiati...
ORGANISM(S): Homo sapiens 
2015-02-20 | E-GEOD-55109 | biostudies-arrayexpress
ProteomicsGrafting induced pluripotent stem cells-derived tenocytes contribute to recovery of motor function after Achilles tendon rupture in rat
Self-renewal of tendons is rare since the vascular formation inside is extremely poor, thus reconstructive surgery using autologous tendons has been often taken place in the case of severe injury. However, the rate of re-injury after surgery is relatively high, and collection of autologous tendons l...
ORGANISM(S): Homo Sapiens (human) 
2021-07-01 | PXD020887 | JPOST Repository
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