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MetabolomicsProteomics and tracer metabolomics link GAPDH ISGylation to glycolytic control

Ubiquitin-like protein ISG15 (interferon-stimulated gene 15) has been implicated in the regulation of central carbon metabolism, but conflicting findings across experimental systems have limited mechanistic insight. Here, we applied a multi-omics approach in cells ectopically expressing the ISGyl...

2026-03-02 | MTBLS12619 | MetaboLights
ProteomicsISGylation of the SARS-CoV-2 N protein by HERC5 impedes N oligomerization and thereby viral RNA synthesis
Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like protein, is covalently conjugated to host immune proteins such as MDA5 and IRF3 in a process called ISGylation, thereby promoting type I interferon (IFN) induction to limit the replication of Severe acute respiratory syndrome coronavirus ...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2024-08-14 | PXD053712 | Pride
Sars-cov-2  n protein  isg15  isgylation  herc5  papain-like protease 
ProteomicsISGylation of H2AX retains MDC1 and facilitates homologous recombination repair causing radioresistance in esophageal adenocarcinoma
High expression of interferon-stimulated gene 15 (ISG15) has been associated with poor survival in patients with esophageal adenocarcinoma (EAC). Like ubiquitin, ISG15 utilizes its C-terminal LRGG motif to post-translationally modify target proteins through a process called ISGylation, thereby influ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD071548 | Pride
Radioresistance H2ax Esophageal adenocarcinoma. Homologous recombination repair (hrr) Isgylation 
GenomicsProtein ISGylation regulated gene expression in mouse mammary epithelial cells
Protein ISGylation regulated gene expression in mouse mammary epithelial cells
PRJNA448145 | ENA
UnknownSpermidine reduces ISGylation and enhances ISG15-USP18 interaction.
Not available
S-EPMC12102389 | biostudies-literature
UnknownIncreased cerebral protein ISGylation after focal ischemia is neuroprotective.
Not available
S-EPMC3323186 | biostudies-literature
ProteomicsMDA-MB-231 MS analysis of ISGylome, GDI2 interactome and total proteome changes in different ISGylation models
Analysis of ISG15 conjugation (Isgylation)role as driver of poor prognosis in non HER2+ breast cancer tumours. The project includes an analysis of total proteome and ISGylome characterization of MDA-MB-231 cells, wild-type or knock-out for the ISGyltaion associated genes, ISG15, UBE2L6 and USP18. Ad...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025753 | Pride
Breast cancer Gdi2 Egfr recycling Isg15 
UnknownProteomics Mapping of the ISGylation Landscape in Innate Immunity.
Not available
S-EPMC8383068 | biostudies-literature
TranscriptomicsProtein ISGylation regulated gene expression in mouse mammary epithelial cells
Purpose: The goals of this study are to use RNA-seq to identify genes whose expression are regulated by protein ISGylation in a genome-wide scale Methods: mRNA profiles of PyVmT/Uba7 KO + Control and PyVmT/Uba7 KO+UBE1L mammary epithelial cells (MECs) were generated by deep-sequecing in duplicates, ...
ORGANISM(S): Mus musculus 
2020-03-27 | GSE112532 | GEO
UnknownDynamic RBM47 ISGylation confers broad immunoprotection against lung injury and tumorigenesis via TSC22D3 downregulation.
Not available
S-EPMC10689852 | biostudies-literature
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