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ProteomicsTruncated N-glycans destabilize POMT1 and POMT2 but do not limit cellular O-mannosylation in HEK293 cells
Protein O-mannosylation is initiated by the ER-resident enzymes POMT1 and POMT2, both of which carry multiple N-glycans essential for proper folding and activity. Although congenital disorders of glycosylation type I (CDG-I) disrupt the early N-glycosylation process, their impact on POMT biogenesis ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-02 | PXD073937 | Pride
Alg3  pomt1  pomt2  kiaa1549  n-glycosylation  o-mannosylation 
ProteomicsKIAA1549::BRAF is cleaved and located at a membrane
We used a Terminal Amine Isotopic Labelling of Substrates (TAILS) mass spectrometry approach to investigate peptides with a neo-N-terminus of the C-terminally HA-tagged fusion protein KIAA1549::BRAF.
ORGANISM(S): Homo sapiens (Human) 
2026-08-03 | PXD062076 | Pride
Lc-msms Mapk Kinase Tails Human 
TranscriptomicsAffymetrix SNP array data for low-grade astrocytoma samples
Copy number analysis of 21 paediatric low-grade astrocytomas identified a discrete copy number gain of 1.9Mb in chromosome band 7q34. The gain was present in 12/14 cerebellar pilocytic astrocytomas. Subsequent analysis of tumour cDNA indentified a novel gene fusion between KIAA1549 and BRAF in these...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14960 | biostudies-arrayexpress
UnknownConditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects.
Not available
S-EPMC3808469 | biostudies-literature
ProteomicsO-mannosylation and protein maturation checkpoints represent therapeutic opportunities in BRAF fusion protein oncogenesis
Fusions between protein-coding genes are common oncogenic drivers across cancers, typically pairing a proto-oncogene with a partner that does not independently drive cancer. In all therapeutically actionable fusions, the proto-oncogene is the drug target, the contributions to oncogenicity of the fus...
ORGANISM(S): Homo sapiens (Human) 
2026-08-02 | PXD078059 | Pride
O-mannosylation Pomt1/2 Kiaa1549 Braf Fusion Oncogenesis 
UnknownDetection of the KIAA1549-BRAF fusion gene in cells forming microvascular proliferations in pilocytic astrocytoma.
Not available
S-EPMC6645544 | biostudies-literature
UnknownKIAA1549: BRAF Gene Fusion and FGFR1 Hotspot Mutations Are Prognostic Factors in Pilocytic Astrocytomas.
Not available
S-EPMC4470527 | biostudies-literature
UnknownWhole Chromosome 7 Gain Predicts Higher Risk of Recurrence in Pediatric Pilocytic Astrocytomas Independently From KIAA1549-BRAF Fusion Status.
Not available
S-EPMC5009478 | biostudies-literature
GenomicsMulti-omics Dissection of MAPK-driven Senescence Unveils Therapeutic Vulnerabilities in KIAA1549::BRAF-fusion Pediatric Low-Grade Glioma Models
Multi-omics Dissection of MAPK-driven Senescence Unveils Therapeutic Vulnerabilities in KIAA1549::BRAF-fusion Pediatric Low-Grade Glioma Models
PRJNA1213793 | ENA
UnknownBRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants.
Not available
S-EPMC4629834 | biostudies-literature
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