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ProteomicsMapping the Interactome of KRAS and Its G12C/D/V Mutants by Integrating TurboID Proximity Labeling with Quantitative Proteomics
RAS is one of the most frequently mutated proto-oncogenes in human malignancies, with mutation sites and subtypes exhibiting tumor-type dependent distribution. Oncogenic RAS mutations will maintain continuously GTP-bound activation states that leading to dysregulation of downstream signaling, ultima...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD062101 | Pride
Kras interactome  kras g12 mutants  turboid proximity-labeling  quantitative proteomics；metabolic reprogramming 
ProteomicsOncogenic Mutations of KRAS Modulate Its Turnover by the CUL3/LZTR1 E3 ligase Complex
KRAS is a proto-oncogene encoding a small GTPase. Mutations contribute up to 30% of human solid tumours including lung adenocarcinoma, pancreatic and colorectal carcinomas. Most KRAS activating mutations interfere with GTP hydrolysis, essential for its role as a molecular switch, leading to alterati...
ORGANISM(S): Homo sapiens (Human) 
2024-03-06 | PXD029725 | Pride
G13d Kras G12d 
UnknownImpact of KRAS-G12 Mutations on the KRAS-GTP Bound Conformational Dynamics: Structure, Free Energy Barriers and Drugging Pockets.
Not available
S-EPMC12933348 | biostudies-literature
UnknownStructure guided analysis of KRAS G12 mutants in HLA-A*11:01 reveals a length encoded immunogenic advantage in G12D.
Not available
S-EPMC12774912 | biostudies-literature
UnknownAssessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling.
Not available
S-EPMC6147662 | biostudies-literature
UnknownKRAS is vulnerable to reversible switch-II pocket engagement in cells.
Not available
S-EPMC9135634 | biostudies-literature
UnknownFunctional and biological heterogeneity of KRASQ61 mutations.
Not available
S-EPMC9534304 | biostudies-literature
GenomicsFOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer
FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer
PRJNA1310415 | ENA
GenomicsMolecular characterisation of a mutant kras-driven zebrafish model of hepatocellular carcinoma
Molecular characterisation of a mutant kras-driven zebrafish model of hepatocellular carcinoma
PRJNA909412 | ENA
UnknownDriver and targetable alterations in Chinese patients with small bowel carcinoma.
Not available
S-EPMC11796673 | biostudies-literature
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