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ProteomicsLima1 mediates the pluripotency control of membrane dynamics and cellular metabolism
Lima1 is an extensively studied prognostic marker of malignancy and is also considered to be a tumour suppressor, but its role in a developmental context of non-transformed cells is poorly understood. Here, we characterised the expression pattern and examined the function of Lima1 in mouse embryos a...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-16 | PXD025293 | Pride
Lc-msms Stem cells Proteomics Pluripotency Development Lim domain and actin binding 1 Lima1 Eplin 
ProteomicsThe Influences of ApoE Isoforms on Endothelial Adherens Junctions and Actin Cytoskeleton Responding to mCRP
Monomeric C-reactive protein (mCRP) plays a role in cerebrovascular damage mediated by apolipoprotein E4 (ApoE4) in Alzheimer's disease (AD) pathogenesis. Using proteomic profilings, we found altered cytoskeleton proteins in the microvasculature of AD brains, including increased levels of hyperphosp...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-05-06 | PXD051529 | Pride
Apolipoprotein e (apoe)  monomeric c-reactive protein (mcrp)  lim domain and actin binding 1 (lima1)  cd31 and pcd31  cerebrovascular  endothelia  f-actin  alzheimer’s disease (ad) 
UnknownLIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism.
Not available
S-EPMC11193757 | biostudies-literature
UnknownOverexpression of LIMA1 Indicates Poor Prognosis and Promotes Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.
Not available
S-EPMC9274436 | biostudies-literature
UnknownThe Relationship between the Prognostic Marker LIMA1 in Head and Neck Squamous Cell Carcinoma and Immune Infiltration.
Not available
S-EPMC10175016 | biostudies-literature
UnknownBisphosphate nucleotidase 1 promotes progression and docetaxel resistance in triple-negative breast cancer via STUB1-mediated destabilization of LIMA1.
Not available
S-EPMC12808305 | biostudies-literature
UnknownCAF-Released Exosomal miR-20a-5p Facilitates HCC Progression via the LIMA1-Mediated β-Catenin Pathway.
Not available
S-EPMC9740131 | biostudies-literature
ProteomicsEPLIN-Beta is a novel substrate of ornithine decarboxylase antizyme 1, mediating cellular migration
Polyamines promote cellular proliferation, and their levels are controlled by ornithine decarboxylase antizyme 1 (Az1), through the proteasome-mediated, ubiquitin-independent degradation of ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis. Az1-mediated degradation of...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD039865 | Pride
Ubiquitin-independent degradation Antizyme Cell migration Eplin/lima1 
UnknownLIMA1 O-GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β-catenin-Regulated FASn Expression in Metabolic Dysfunction-Associated Steatotic Liver Disease.
Not available
S-EPMC12005730 | biostudies-literature
UnknownLIMA1 inhibits cisplatin resistance and malignant biological behavior of bladder cancer cells by suppressing the Wnt/β-catenin pathway.
Not available
S-EPMC12016094 | biostudies-literature
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