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MetabolomicsComparative 1H-NMR Lipoprotein Profiling of Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Highlights Disease-Specific Lipoprotein Dysregulation

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are systemic autoimmune diseases associated with increased cardiovascular risk and metabolic alterations. We applied 1H-NMR spectroscopy to profile lipoproteins and metabolites in women with RA, SLE, and healthy controls. Both RA an...

2026-02-02 | MTBLS13820 | MetaboLights
MetabolomicsMetabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess
Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks re...
2015-04-09 | MTBLS103 | MetaboLights
TranscriptomicsGene expression profiling of GPR86 (P2RY13) KO mice
The purinergic receptor P2Y13 (P2RY13) has been shown to play a role in the uptake of holo-HDL particles in in vitro hepatocyte experiments. In order to determine the role of P2Y13 in lipoprotein metabolism in vivo, we ablated the expression of this gene in mice and found that P2Y13 knockout mice ha...
ORGANISM(S): Mus musculus 
2010-09-10 | E-GEOD-20920 | biostudies-arrayexpress
ProteomicsEffect of Rosuvastatin on the Lipoprotein Proteome
Statins lower plasma cholesterol by as much as 50%, thus reducing future cardiovascular events. However, the physiological effects of statins are diverse and not all are related to LDL-C lowering. We performed a small clinical pilot study to assess the impact of statins on lipoprotein-associated pro...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002633 | Pride
Lipoprotein Rosuvastatin Ldl Statin Hdl 
TranscriptomicsMicroRNAs are Transported in Plasma and Delivered to Recipient Cells by High-Density Lipoproteins (HG-U133 2.0)
Circulating microRNAs (miRNA) are relatively stable in plasma and are a new class of disease biomarkers. Here we present evidence that human high-density lipoprotein (HDL) transports endogenous miRNAs and delivers them to recipient cells with functional targeting capabilities. Highly-purified fracti...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-25311 | biostudies-arrayexpress
ProteomicsWNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
WNTs are hydrophobic, lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules reach over long distances in the mammalian brain. Here we show that WNT5A is produced by the choroid pl...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-01-14 | PXD011918 | Pride
Co-immunoprecipitation Wnt5a Lc-ms/ms 
ProteomicsHuman HDL 2D-LC-MS/MS
Besides modulation of reverse cholesterol transport, high density lipoprotein (HDL) is able to modulate vascular function by stimulating endothelial nitric oxide synthase. Recently, it could be documented that this function of HDL was significantly impaired in patients with chronic heart failure (CH...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080857 | MassIVE
MetabolomicsQuantitative profiling of endocannabinoids in lipoproteins by LC–MS/MS
Endocannabinoids belong to a diverse family of endogenous lipid bioregulators acting as physiological ligands of cannabinoid receptor type 1 and cannabinoid receptor type 2 in the central and peripheral nervous system. They are also present in nmol/l concentrations in human blood plasma; however, th...
2015-03-11 | MTBLS163 | MetaboLights
TranscriptomicsUbiquinol-induced gene expression signatures are translated into reduced erythropoiesis and LDL cholesterol levels in humans
Studies in vitro and in mice indicate a role for Coenzyme Q10 (CoQ10) in gene expression. To determine this function in relationship to physiological readouts, a 2-week supplementation study with the reduced form of CoQ10 (ubiquinol, Q10H2, 150 mg/d) was performed in 53 healthy males. Mean CoQ10 pla...
ORGANISM(S): Homo sapiens 
2013-04-08 | E-GEOD-21351 | biostudies-arrayexpress
TranscriptomicsFenofibrate increases VLDL-triglyceride production despite reducing plasma triglyceride levels in APOE*3-Leiden.CETP mice
The PPAR? activator fenofibrate efficiently decreases plasma triglycerides (TG), which is generally attributed to enhanced VLDL-TG clearance and decreased VLDL-TG production. However, since data on the effect of fenofibrate on VLDL production are controversial, we aimed to investigate in (more) deta...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21211 | biostudies-arrayexpress
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