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MetabolomicsHigh-performance nano-flow liquid chromatography column combined with high- and low-collision energy data-independent acquisition enables targeted and discovery identification of modified ribonucleotides by mass spectrometry (Data-independent acquisition)

Over 170 post-transcriptional RNA modifications have been described and are common in all kingdoms of life. These modifications range from methylation to complex chemical structures, with methylation being the most abundant. RNA modifications play a key role in RNA folding and function and their ...

2023-10-26 | MTBLS2959 | MetaboLights
MetabolomicsHigh-performance nano-flow liquid chromatography column combined with high- and low-collision energy data-independent acquisition enables targeted and discovery identification of modified ribonucleotides by mass spectrometry (Mixed-mode column chromatography)

Over 170 post-transcriptional RNA modifications have been described and are common in all kingdoms of life. These modifications range from methylation to complex chemical structures, with methylation being the most abundant. RNA modifications play a key role in RNA folding and function and their ...

2023-10-26 | MTBLS2497 | MetaboLights
MetabolomicsAlignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites

Acute febrile illnesses are still a major cause of mortality and morbidity globally, particularly in low to middle income countries. The aim of this study was to determine any possible metabolic commonalities of patients infected with disparate pathogens that cause fever. Three liquid chromatogra...

2023-07-17 | MTBLS4895 | MetaboLights
MetabolomicsUntargeted LC-MS metabolomics for the analysis of micro-scaled extracellular metabolites from hepatocytes
Metabolome analysis in micro physiological models is a challenge due to the low volume of cell culture medium (CCM). Here, we report a LC-MS-based untargeted metabolomics protocol for the detection of hepatocyte extracellular metabolites from micro-scale samples of CCM. Using a single LC-MS method w...
2021-01-04 | MTBLS1794 | MetaboLights
MetabolomicsUntargeted LC-MS metabolomics of contaminated soil samples
Untargeted LC-MS metabolomics was performed on six contaminated soil samples divided into two experimental groups (A and B) to characterize metabolic profiles and investigate differences between the groups. Samples were analyzed in both positive and negative ionization modes using UHPLC coupled to h...
2026-10-07 | MTBLS15935 | MetaboLights
MetabolomicsUntargeted LC-MS metabolomic profiling of Tulipa iliensis leaves during Botrytis tulipae infection
This study investigated the metabolic responses of Tulipa iliensis leaves to Botrytis tulipae infection using untargeted LC-MS metabolomics. Leaf tissues were collected at 0, 6, 12, 24, 48 and 72 h post-inoculation, with three biological replicates per time point. All samples were snap-frozen in liq...
2027-08-19 | MTBLS15393 | MetaboLights
MetabolomicsChlorel-lc-ms non-targeted metabolomics

The salinity of aquaculture wastewater varies considerably across farming systems, limiting the applicability of conventional Chlorella strains. To improve salt tolerance and broaden application potential, atmospheric and room temperature plasma (ARTP) mutagenesis was employed. 

2025-09-30 | MTBLS13082 | MetaboLights
MetabolomicsSerum LC-MS metabolomics profiling during musk secretion in captive forest musk deer (Moschus berezovskii)
This study investigates serum metabolomic changes associated with musk secretion in captive male forest musk deer (Moschus berezovskii). Paired serum samples were collected before secretion and during secretion and analyzed using LC-MS in both positive and negative ion modes. The study includes biol...
2026-04-23 | MTBLS14280 | MetaboLights
MetabolomicsTargeted LC-MS analysis for lipidomics of mice intestinal samples

Mice of C57BL/6 were received a single dose of 12 Gy of the whole abdominal radiation (WART) to establish acute radiation bowel injury model. Approximately 12 hours post-irradiation, mice were orally administrated with PBS, DY802 and TG-CS@DY802 respectively. For 5 days consecutive treatment...

2026-04-02 | MTBLS14210 | MetaboLights
MetabolomicsLipidHunter Identifies Phospholipids by High-Throughput Processing of LC-MS and Shotgun Lipidomics Datasets (Rat cardiomyocyte assay)
Lipids are dynamic constituents of biological systems, rapidly responding to any changes in physiological conditions. Thus, there is a large interest in lipid-derived markers for diagnostic and prognostic applications, especially in translational and systems medicine research. As lipid identificatio...
2018-07-31 | MTBLS483 | MetaboLights
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