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ProteomicsGlycoproteoforms of Integrins α2 and β1 in Megakaryocytes in the Occurrence of Primary Myelofibrosis
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm prone to leukemic transformation, for which limited treatment is available. Amongst individuals diagnosed with PMF, the most prevalent mutation is the JAK2V617F somatic point mutation that activates the Janus kinase 2 (JAK2) enzyme. Our ea...
ORGANISM(S): Mesocricetus auratus (Golden hamster) Mus musculus (Mouse) 
2022-02-22 | PXD030550 | Pride
Integrins  megakaryocytes  primary myelofibrosis  lc-ms/ms  glycopeptiforms 
TranscriptomicsMicroRNA expression during murine fetal liver megakaryocyte differentiation
MicroRNAs are small non-coding RNAs that regulate cellular development by interfering with mRNA stability and translation. We defined the kinetics of global microRNA expression during the differentiation of murine hematopoietic progenitors into megakaryocytes. Of 435 miRNAs analyzed, 13 were upreg...
ORGANISM(S): Mus musculus 
2010-12-07 | E-GEOD-22480 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of megakaryocyte cells from Gata-1 knock out mice and wild type mice to study the differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development
Hematopoietic progenitor cells were isolated from 13.5 day mouse fetal livers by lineage depletion and expanded for three days. Fetal livers were isolated from both wild type and Gata-1 knock embryos. Gata-1 knock embryos contain a deletion of the Gata-1 promoter sequence that results in undetectabl...
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-2527 | biostudies-arrayexpress
TranscriptomicsRNA-seq of coding RNA of in vitro differentiated megakaryocytes
Transcription profiling of in vitro differentiated megakaryocytes
ORGANISM(S): Homo sapiens 
2011-11-04 | E-MTAB-918 | biostudies-arrayexpress
TranscriptomicsPF4-Cre mediated deletion of SRF in murine megakaryocytes.
Srf is a MADS-box transcription factor that is critical for muscle differentiation. Its function in hematopoiesis has not yet been revealed. Mkl1, a cofactor of Srf, is part of the t(1;22) translocation in acute megakaryoblastic leukemia, and plays a critical role in megakaryopoiesis. In order to te...
ORGANISM(S): Mus musculus 
2010-07-13 | E-GEOD-21859 | biostudies-arrayexpress
GenomicsMicroarray comparison of adult peripheral blood megakaryocytes to umbilical cord blood-derived megakaryocytes
Microarray comparison of adult peripheral blood megakaryocytes to umbilical cord blood-derived megakaryocytes
PRJNA1102303 | ENA
ProteomicsPathogenesis of dominant-negative mutant GFI1B and associated proteomic abnormalities in megakaryocytes and platelets
Dominant-negative mutations in transcription factor Growth Factor Independence-1B (GFI1B) cause a bleeding disorder characterized by a plethora of megakaryocyte and platelet abnormalities. The deregulated molecular mechanisms and pathways are unknown. Here we show that normal and mutant GFI1B inter...
ORGANISM(S): Homo sapiens (Human) 
2019-01-25 | PXD009020 | Pride
Megakaryocytes Lsd1 Bleeding disorder Lc-ms Proteomics Platelet Gfi1b 
TranscriptomicsTranscription profiling by array of mouse bone marrow lineage- c-Kit+ Sca-1+ cells in which floxed Mpl alleles were specifically and homozygously deleted in megakaryocytes and platelets
Thrombopoietin (TPO) acting via its receptor Mpl is the major cytokine regulator of platelet number. To precisely define the role of specific hematopoietic cells in TPO dependent hematopoiesis, we generated mice that express the Mpl receptor normally on stem/progenitor cells but lack expression on m...
ORGANISM(S): Mus musculus 
2014-06-10 | E-MTAB-2389 | biostudies-arrayexpress
TranscriptomicsImpact of Elevated Plasma 5-HT on Global Gene Expression of Murine Megakaryocytes
The goal of this project was to understand the functional consequences of plasma biogenic amine serotonin (5-HT) elevation in megakaryocytes by measuring gene expression Total RNA was extracted from the megakaryocytes of mice treated with either 5-HT or saline and global gene expression was measured...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-37273 | biostudies-arrayexpress
GenomicsGene expression profiles of cultured megakaryocytes
Gene expression profiles of cultured megakaryocytes
PRJNA449084 | ENA
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