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GenomicsRisk alleles of membranous nephropathy and recurrence of the disease on the grafted kidney
The goal of the project was to identify risk alleles that are associated with recurrence of membranous nephropathy in the graft after kidney transplantation. First, we sequenced PLA2R1 and HLA-D loci in 248 patients with primary membranous nephropathy and identified two independent single nucleotide...
EGAS00001005435 | EGA
ProteomicsUrine complement analysis implies complement activation is involved in membranous nephropathy
Total 1,427 differentially expressed proteins were identified between the MN and HC groups. KEGG pathway analysis showed significant enrichment of these DEPs in the complement-activated pathway within the MN group. Additionally, a correlation was found between proteinuria and the levels of 27 urinar...
ORGANISM(S): Homo Sapiens 
2025-02-01 | PXD060494 |
GenomicsGWAS for Membranous Nephropathy
GWAS for Membranous Nephropathy
PRJNA609184 | ENA
GenomicsGWAS for Membranous Nephropathy
GWAS for Membranous Nephropathy
PRJNA609185 | ENA
ProteomicsMinor Antigens in Membranous Nephropathy Identified by Mass Spectrometry
Background: Multiple autoantigens have been identified in membranous nephropathy (MN) by tissue-based proteomics. However, the antigenic targets of disease are unknown for >10% of MN and >50% of membranous lupus nephritis (MLN) cases. We identified multiple new targets in PLA2R-/THSD7A-/EXT-/NELL1-q...
ORGANISM(S): Homo sapiens (Human) 
2023-04-06 | PXD035854 | Pride
Human Kidney Pulldown Membranous nephropathy Dda 
ProteomicsMinor Antigens in Membranous Nephropathy Identified by Mass Spectrometry
Background: Multiple autoantigens have been identified in membranous nephropathy (MN) by tissue-based proteomics. However, the antigenic targets of disease are unknown for >10% of MN and >50% of membranous lupus nephritis (MLN) cases. We identified multiple new targets in PLA2R-/THSD7A-/EXT-/NELL1-q...
ORGANISM(S): Homo sapiens (Human) 
2023-04-06 | PXD035853 | Pride
Human Dia Kidney Pulldown Membranous nephropathy Dda 
ProteomicsDeficiency of THSD7A reverses glomerular proteomic profiles in anti-THSD7A antibody induced membranous nephropathy models
Proteomics experiment 3/3 associated with this work. THSD7A is a key podocyte antigen in membranous nephropathy (MN), an antibody-mediated autoimmune disease. While the pathogenic role of autoantibodies targeting THSD7A in MN is well described, the consequences of autoantibody binding for podocyte h...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-30 | PXD065344 | Pride
Anti-thsd7a antibody induced membranous nephropathy Podocyte injury Experimental membranous nephropathy 
UnknownObinutuzumab and Ofatumumab are More Effective Than Rituximab in the Treatment of Membranous Nephropathy Patients With Anti-Rituximab Antibodies.
Not available
S-EPMC11993203 | biostudies-literature
GenomicsIdiopathic membranous nephropathy and minimal change disease (MCD) transcriptome
Idiopathic membranous nephropathy and minimal change disease (MCD) transcriptome
PRJNA895478 | ENA
ProteomicsFat1 is atarget antigen in de novo allograft membranous nephropoathy associated with antibody mediated rejection.
Membranous nephropathy (MN) occurs either as recurrent or de novo MN in the kidney allograft. Recurrent MN is most often associated with antibodies to the target antigen M-type phospholipase A2 receptor (PLA2R). 1-3 Most cases of de novo MN are PLA2R-negative and the target antigen in unknown.2 We h...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD055559 | Pride
Kidney transplant. Fat1 De novo membranous nephropathy 
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